Chloroxine
Capitrol (chloroxine) is a small molecule pharmaceutical. Chloroxine was first approved as Capitrol on 1982-01-01. It is used to treat scalp dermatoses and seborrheic dermatitis in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroxine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CAPITROL | Westwood-Squibb Pharmaceuticals | N-017594 DISCN | 1982-01-01 | 1 products |
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Agency Specific
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Clinical
Clinical Trials
267 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 11 | 71 | 54 | 14 | 66 | 192 |
| Hepatocellular carcinoma | D006528 | C22.0 | 5 | 17 | 3 | 2 | 11 | 35 | |
| Colorectal neoplasms | D015179 | — | 2 | — | 1 | 1 | 4 | ||
| Neoplasm metastasis | D009362 | EFO_0009708 | 1 | 2 | — | 1 | — | 3 | |
| Thrombosis | D013927 | — | — | — | 1 | 1 | 2 | ||
| Circulating neoplastic cells | D009360 | — | — | — | 1 | 1 | 2 | ||
| Therapeutic chemoembolization | D016461 | — | — | — | 1 | — | 1 | ||
| Ablation techniques | D055011 | — | — | — | 1 | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma | D018281 | C22.1 | — | 7 | — | — | 1 | 8 | |
| Neoplasms | D009369 | C80 | — | 3 | — | — | — | 3 | |
| Digestive system neoplasms | D004067 | — | 3 | — | — | — | 3 | ||
| Biliary tract neoplasms | D001661 | C24.9 | 1 | 2 | — | — | — | 2 | |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 2 | — | — | — | 2 |
| Bile duct neoplasms | D001650 | — | 1 | — | — | — | 1 | ||
| Adenocarcinoma | D000230 | — | 1 | — | — | — | 1 | ||
| Neoplasms by histologic type | D009370 | — | 1 | — | — | — | 1 | ||
| Neoplasms by site | D009371 | — | 1 | — | — | — | 1 | ||
| Glandular and epithelial neoplasms | D009375 | — | 1 | — | — | — | 1 |
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | — | — | — | 2 | 2 |
| Molecular targeted therapy | D058990 | — | — | — | — | 1 | 1 | ||
| Liver failure | D017093 | HP_0001399 | K72.9 | — | — | — | — | 1 | 1 |
| Survival rate | D015996 | — | — | — | — | 1 | 1 | ||
| Liver transplantation | D016031 | EFO_0010682 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CHLOROXINE |
| INN | — |
| Description | Chloroxine is a monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp. It has a role as an antibacterial agent, an antiseborrheic and an antifungal drug. It is a monohydroxyquinoline and an organochlorine compound. It is functionally related to a quinolin-8-ol. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Oc1c(Cl)cc(Cl)c2cccnc12 |
Identifiers
| PDB | — |
| CAS-ID | 773-76-2 |
| RxCUI | 20875 |
| ChEMBL ID | CHEMBL1200596 |
| ChEBI ID | 59477 |
| PubChem CID | 2722 |
| DrugBank | DB01243 |
| UNII ID | — |
Target
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Safety
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2 adverse events reported
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