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Chlorpromazine
Promapar, Sonazine, Thorazine (chlorpromazine) is a small molecule pharmaceutical. Chlorpromazine was first approved as Thorazine on 1982-01-01. It is used to treat acute intermittent porphyria, anxiety disorders, attention deficit and disruptive behavior disorders, child behavior disorders, and hiccup amongst others in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2A. In addition, it is known to target D(1B) dopamine receptor, D(1A) dopamine receptor, short transient receptor potential channel 5, histamine H1 receptor, D(3) dopamine receptor, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 7, alpha-2B adrenergic receptor, D(4) dopamine receptor, D(2) dopamine receptor, alpha-2A adrenergic receptor, alpha-2C adrenergic receptor, 5-hydroxytryptamine receptor 1A, and 5-hydroxytryptamine receptor 2C.
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Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpromazine
Tradename
Company
Number
Date
Products
THORAZINEGSKN-009149 DISCN1982-01-01
2 products, RLD
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Chlorpromazine hydrochloride
Tradename
Company
Number
Date
Products
THORAZINEGSKN-009149 DISCN1982-01-01
9 products, RLD
THORAZINEGSKN-011120 DISCN1982-01-01
5 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
chlorpromazine hydrochlorideANDA2023-04-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acute intermittent porphyria—D017118—
anxiety disordersEFO_0006788D001008F41.1
attention deficit and disruptive behavior disordersHP_0010865D019958F91.3
child behavior disorders—D002653—
hiccup—D006606R06.6
nauseaHP_0002018D009325R11.0
psychotic disorders—D011618F20.81
schizophreniaEFO_0000692D012559F20
tetanusEFO_0005593D013742A35
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AA: Phenothiazines with aliphatic side-chain, antipsychotics
— N05AA01: Chlorpromazine
HCPCS
Code
Description
J3230
Injection, chlorpromazine hcl, up to 50 mg
Q0161
Chlorpromazine hydrochloride, 5 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C251————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLORPROMAZINE
INNchlorpromazine
Description
Chlorpromazine is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. It has a role as a phenothiazine antipsychotic drug, an antiemetic, a dopaminergic antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an anticoronaviral agent. It is a member of phenothiazines, an organochlorine compound and a tertiary amine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21
Identifiers
PDB5LG3
CAS-ID50-53-3
RxCUI2403
ChEMBL IDCHEMBL71
ChEBI ID3647
PubChem CID2726
DrugBankDB00477
UNII IDU42B7VYA4P (ChemIDplus, GSRS)
Target
Agency Approved
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR2A
Gene synonyms
HTR2
NCBI Gene ID
3356
Protein name
5-hydroxytryptamine receptor 2A
Protein synonyms
5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor, Serotonin receptor 2A
Uniprot ID
Q5T8C0
Mouse ortholog
Htr2a (15558)
5-hydroxytryptamine receptor 2A (P35363)
Alternate
DRD5
DRD5
DRD1
DRD1
TRPC5
TRPC5
HRH1
HRH1
DRD3
DRD3
HTR6
HTR6
HTR7
HTR7
ADRA2B
ADRA2B
DRD4
DRD4
DRD2
DRD2
ADRA2A
ADRA2A
ADRA2C
ADRA2C
HTR1A
HTR1A
HTR2C
HTR2C
Organism
Homo sapiens
Gene name
DRD5
Gene synonyms
DRD1B, DRD1L2
NCBI Gene ID
1816
Protein name
D(1B) dopamine receptor
Protein synonyms
D(5) dopamine receptor, D1beta dopamine receptor, Dopamine D5 receptor, dopamine receptor D1B
Uniprot ID
Q8NEQ8
Mouse ortholog
Drd5 (13492)
D(1B) dopamine receptor (Q8BLD9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 24,184 documents
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Safety
Black-box Warning
Black-box warning for: Chlorpromazine hydrochloride
Adverse Events
Top Adverse Reactions
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9 adverse events reported
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