Chlorpropamide
Diabinese, Glucamide (chlorpropamide) is a small molecule pharmaceutical. Chlorpropamide was first approved as Diabinese on 1982-01-01. It is used to treat type 2 diabetes mellitus in the USA. It is known to target ATP-binding cassette sub-family C member 8.
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Commercial
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpropamide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIABINESE | Mylan | N-011641 DISCN | 1982-01-01 | 2 products, RLD |
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| type 2 diabetes mellitus | EFO_0001360 | D003924 | E11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 2 | 1 | 4 |
| Aggression | D000374 | EFO_0003015 | — | — | — | 1 | — | 1 | |
| Psychotic disorders | D011618 | F20.81 | — | — | — | 1 | — | 1 | |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Delirium | D003693 | R41.0 | — | 2 | 2 | — | — | 2 | |
| Covid-19 | D000086382 | U07.1 | — | 1 | 2 | — | — | 2 | |
| Neonatal abstinence syndrome | D009357 | EFO_0005799 | P96.1 | — | — | 1 | — | — | 1 |
| Neoplasms | D009369 | C80 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | 1 | 1 | — | — | — | 2 | |
| Colonic neoplasms | D003110 | C18 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | 1 | — | — | — | — | 1 |
| Psychomotor agitation | D011595 | 1 | — | — | — | — | 1 | ||
| Acute intermittent porphyria | D017118 | 1 | — | — | — | — | 1 | ||
| Oral manifestations | D009912 | 1 | — | — | — | — | 1 | ||
| Tetanus | D013742 | EFO_0005593 | A35 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CHLORPROPAMIDE |
| INN | chlorpropamide |
| Description | Chlorpropamide is an N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification. It has a role as a hypoglycemic agent and an insulin secretagogue. It is a N-sulfonylurea and a member of monochlorobenzenes. |
| Classification | Small molecule |
| Drug class | diuretics (sulfamoylbenzoic acid derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 94-20-2 |
| RxCUI | 2404 |
| ChEMBL ID | CHEMBL498 |
| ChEBI ID | 3650 |
| PubChem CID | 2727 |
| DrugBank | DB00672 |
| UNII ID | WTM2C3IL2X (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ABCC8
ABCC8
Organism
Homo sapiens
Gene name
ABCC8
Gene synonyms
HRINS, SUR, SUR1
NCBI Gene ID
Protein name
ATP-binding cassette sub-family C member 8
Protein synonyms
ATP-binding cassette transporter sub-family C member 8, ATP-binding cassette, sub-family C (CFTR/MRP), member 8, sulfonylurea receptor (hyperinsulinemia), Sulfonylurea receptor 1
Uniprot ID
Mouse ortholog
Abcc8 (20927)
ATP-binding cassette sub-family C member 8 (B2RUS7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,148 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,005 adverse events reported
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