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Cholestyramine
Cholybar, Questran (cholestyramine) is a small molecule pharmaceutical. Cholestyramine was first approved as Questran on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cholestyramine
Tradename
Company
Number
Date
Products
QUESTRANBristol Myers SquibbN-016640 DISCN1982-01-01
2 products, RLD
QUESTRAN LIGHTBristol Myers SquibbN-019669 DISCN1988-12-05
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
cholestyramineANDA2023-05-25
prevaliteANDA2020-06-18
questranANDA2019-11-01
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C10: Lipid modifying agents
— C10A: Lipid modifying agents, plain
— C10AC: Bile acid sequestrants
— C10AC01: Colestyramine
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149G89.18———1—1
Knee osteoarthritisD020370EFO_0004616M17———1—1
Hip osteoarthritisD015207EFO_1000786M16———1—1
AlcoholismD000437EFO_0003829F10.1———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD0105992————2
Drug interactionsD0043471————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHOLESTYRAMINE
INNcolestyramine
Description
Colestyramine (INN) or cholestyramine (USAN) (trade names Questran, Questran Light, Cholybar, Olestyr) is a bile acid sequestrant, which binds bile in the gastrointestinal tract to prevent its reabsorption. It is a strong ion exchange resin, which means it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a quaternary ammonium group attached to an inert styrene-divinylbenzene copolymer.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID11041-12-6
RxCUI2447
ChEMBL IDCHEMBL1201625
ChEBI ID—
PubChem CID70695640
DrugBankDB01432
UNII ID4B33BGI082 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,700 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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509 adverse events reported
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