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Cipargamin
Cipargamin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target Non-SERCA-type Ca2+ -transporting P-ATPase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B5414———5
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Falciparum malariaD016778EFO_0007444B501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCIPARGAMIN
INNcipargamin
Description
Cipargamin (NITD609, KAE609) is an experimental synthetic antimalarial drug belonging to the spiroindolone class. The compound was developed at the Novartis Institute for Tropical Diseases in Singapore, through a collaboration with the Genomics Institute of the Novartis Research Foundation (GNF), the Biomedical Primate Research Centre and the Swiss Tropical Institute.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]2(N1)C(=O)Nc1ccc(Cl)cc12
Identifiers
PDB—
CAS-ID1193314-23-6
RxCUI—
ChEMBL IDCHEMBL1082723
ChEBI ID—
PubChem CID44469321
DrugBankDB12306
UNII IDZ7Q4FWA04P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
Organism
Plasmodium falciparum (isolate 3D7)
Gene name
Gene synonyms
NCBI Gene ID
—
Protein name
Non-SERCA-type Ca2+ -transporting P-ATPase
Protein synonyms
Uniprot ID
A0A143ZZK9
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 151 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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