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Citarinostat
Citarinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histone deacetylase 6. In addition, it is known to target histone deacetylase 8, histone deacetylase 2, histone deacetylase 1, and histone deacetylase 3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.01————1
Smoldering multiple myelomaD0000751221————1
MelanomaD0085451————1
Non-small-cell lung carcinomaD0022891————1
NeoplasmsD009369C801————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCITARINOSTAT
INNcitarinostat
Description
Citarinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histone deacetylase 6. In addition, it is known to target histone deacetylase 8, histone deacetylase 2, histone deacetylase 1, and histone deacetylase 3.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(CCCCCCNC(=O)c1cnc(N(c2ccccc2)c2ccccc2Cl)nc1)NO
Identifiers
PDB—
CAS-ID1316215-12-9
RxCUI—
ChEMBL IDCHEMBL3693786
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID441P620G3P (ChemIDplus, GSRS)
Target
Agency Approved
HDAC6
HDAC6
Organism
Homo sapiens
Gene name
HDAC6
Gene synonyms
KIAA0901
NCBI Gene ID
10013
Protein name
histone deacetylase 6
Protein synonyms
protein phosphatase 1, regulatory subunit 90, Tubulin-lysine deacetylase HDAC6
Uniprot ID
Q9UBN7
Mouse ortholog
Hdac6 (15185)
histone deacetylase 6 (Q9Z2V5)
Alternate
HDAC8
HDAC8
HDAC2
HDAC2
HDAC1
HDAC1
HDAC3
HDAC3
Organism
Homo sapiens
Gene name
HDAC8
Gene synonyms
HDACL1
NCBI Gene ID
55869
Protein name
histone deacetylase 8
Protein synonyms
histone deacetylase-like 1, Protein deacetylase HDAC8, Protein decrotonylase HDAC8
Uniprot ID
Q9BY41
Mouse ortholog
Hdac8 (70315)
histone deacetylase 8 (Q8VH37)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 98 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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