Citicoline
Citicoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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HCPCS
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Clinical
Clinical Trials
45 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | 1 | 3 | 4 |
Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 2 | 1 | 3 |
Cerebral infarction | D002544 | I63 | — | — | 1 | 1 | — | 2 | |
Cocaine-related disorders | D019970 | F14 | — | — | 1 | 1 | — | 2 | |
Ischemic optic neuropathy | D018917 | EFO_1000809 | H47.01 | — | — | — | 2 | — | 2 |
Alcoholism | D000437 | EFO_0003829 | F10.1 | — | — | — | 2 | — | 2 |
Delirium | D003693 | R41.0 | — | — | — | 1 | — | 1 | |
Neural conduction | D009431 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Traumatic brain injuries | D000070642 | S06 | — | 1 | 1 | — | 1 | 3 | |
Ischemic stroke | D000083242 | 1 | — | 1 | — | — | 2 | ||
Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | — | — | 2 |
Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | — | — | 1 | — | 1 | 2 |
Mania | D000087122 | F30 | — | — | 1 | — | — | 1 | |
Hypoxia | D000860 | R09.02 | — | — | 1 | — | — | 1 | |
Brain hypoxia-ischemia | D020925 | EFO_1000846 | P91.6 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Schizophrenia | D012559 | EFO_0000692 | F20 | — | 2 | — | — | — | 2 |
Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | 1 | 2 |
Brain injuries | D001930 | S06.9 | — | 1 | — | — | — | 1 | |
Marijuana abuse | D002189 | EFO_0007191 | F12 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | — | — | 4 | 4 | ||
Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | — | — | — | — | 1 | 1 |
Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 1 | 1 |
Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | — | — | — | — | 1 | 1 |
Uveal neoplasms | D014604 | EFO_1001230 | — | — | — | — | 1 | 1 | |
Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common name | CITICOLINE |
INN | citicoline |
Description | CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+). |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)[C@H](O)[C@@H]1O |
Identifiers
PDB | — |
CAS-ID | 987-78-0 |
RxCUI | 997602 |
ChEMBL ID | CHEMBL1618340 |
ChEBI ID | 49086 |
PubChem CID | 13804 |
DrugBank | DB12153 |
UNII ID | 536BQ2JVC7 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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113 adverse events reported
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