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Clemizole
Clemizole is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target short transient receptor potential channel 6, short transient receptor potential channel 4, short transient receptor potential channel 3, and short transient receptor potential channel 5.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myoclonic epilepsiesD004831EFO_1001900G40.411———2
Liver neoplasmsD008113EFO_1001513C22.0—1———1
Lennox gastaut syndromeD065768G40.81—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis cD006526B19.21————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCLEMIZOLE
INNclemizole
Description
Clemizole is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively. It has a role as a histamine antagonist. It is a member of pyrrolidines, a member of benzimidazoles and a member of monochlorobenzenes. It is a conjugate base of a clemizole(1+). It derives from a hydride of a 1H-benzimidazole.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1
Identifiers
PDB—
CAS-ID442-52-4
RxCUI—
ChEMBL IDCHEMBL1407943
ChEBI ID52140
PubChem CID2782
DrugBankDB15932
UNII IDT97CB3796L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TRPC6
TRPC6
TRPC4
TRPC4
TRPC3
TRPC3
TRPC5
TRPC5
Organism
Homo sapiens
Gene name
TRPC6
Gene synonyms
TRP6
NCBI Gene ID
7225
Protein name
short transient receptor potential channel 6
Protein synonyms
focal segmental glomerulosclerosis 2, Transient receptor protein 6, TRP-6
Uniprot ID
Q9Y210
Mouse ortholog
Trpc6 (22068)
short transient receptor potential channel 6 (Q9Z2J1)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 352 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6 adverse events reported
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