Clobazam
Onfi, Sympazan (clobazam) is a small molecule pharmaceutical. Clobazam was first approved as Onfi on 2011-10-21. It is used to treat lennox gastaut syndrome and seizures in the USA.
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Commercial
Trade Name
FDA
EMA
Onfi, Sympazan (generic drugs available since 2018-10-22)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| lennox gastaut syndrome | — | D065768 | G40.81 |
| seizures | HP_0007359 | D012640 | G40.4 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Clinical Trials
29 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | 2 | 9 | 4 | 1 | 16 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | 2 | — | 1 | — | 3 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | — | — | — | 1 | 1 | 2 |
| Cerebral hemorrhage | D002543 | — | — | — | 1 | — | 1 | ||
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | 1 | — | 1 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | 1 | — | 1 |
| Aortic diseases | D001018 | — | — | — | 1 | — | 1 | ||
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | — | — | 1 | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 2 | — | — | 2 |
| Dyspnea | D004417 | HP_0002094 | R06.0 | — | — | 1 | — | — | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | — | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | 1 | — | — | — | 1 | ||
| Intracranial aneurysm | D002532 | EFO_0003870 | I67.1 | — | 1 | — | — | — | 1 |
| Intracranial vasospasm | D020301 | EFO_1000994 | G45.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CLOBAZAM |
| INN | clobazam |
| Description | Clobazam is 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics. It has a role as an anticonvulsant, an anxiolytic drug and a GABA modulator. It is a 1,4-benzodiazepinone and an organochlorine compound. |
| Classification | Small molecule |
| Drug class | Benzodiazepine |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc21 |
Identifiers
| PDB | — |
| CAS-ID | 22316-47-8 |
| RxCUI | 21241 |
| ChEMBL ID | CHEMBL70418 |
| ChEBI ID | 31413 |
| PubChem CID | 2789 |
| DrugBank | DB00349 |
| UNII ID | 2MRO291B4U (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Sympazan - Assertio Therapeutics
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,123 documents
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Safety
Black-box Warning
Black-box warning for: Clobazam, Onfi, Sympazan
Adverse Events
Top Adverse Reactions
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278 adverse events reported
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