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Cloxacillin
Cloxapen, Tegopen (cloxacillin) is a small molecule pharmaceutical. Cloxacillin was first approved as Tegopen on 1982-01-01. It is used to treat bacterial pneumonia, cellulitis, joint diseases, osteomyelitis, and postoperative complications amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
respiratory tract diseasesD012140
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cloxacillin sodium
Tradename
Company
Number
Date
Products
TEGOPENBristol Myers SquibbN-050192 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bacterial pneumoniaEFO_1001272D018410J15.9
cellulitisEFO_0003035D002481L03.90
joint diseasesHP_0003040D007592M12.9
osteomyelitisEFO_0003102D010019M86
postoperative complicationsD011183
staphylococcal skin infectionsEFO_1001849D013207L00
urinary tract infectionsEFO_0003103D014552N39.0
wound infectionD014946
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01C: Beta-lactam antibacterials, penicillins
J01CF: Beta-lactamase resistant penicillins
J01CF02: Cloxacillin
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G4311
HeadacheD006261HP_0002315R5111
Migraine without auraD020326EFO_0005296G43.011
Migraine with auraD020325EFO_0005295G43.111
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCLOXACILLIN
INNcloxacillin
Description
Cloxacillin is a semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. It has a role as an antibacterial agent and an antibacterial drug. It is a semisynthetic derivative, a penicillin allergen and a penicillin. It is functionally related to an oxacillin. It is a conjugate acid of a cloxacillin(1-).
Classification
Small molecule
Drug classpenicillins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@H]12
Identifiers
PDB
CAS-ID61-72-3
RxCUI2625
ChEMBL IDCHEMBL891
ChEBI ID49566
PubChem CID6098
DrugBankDB01147
UNII IDO6X5QGC2VB (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,752 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,150 adverse events reported
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