Corticotropin
Acthar, Cortrophin (corticotropin) is a protein pharmaceutical. Corticotropin was first approved as Purified cortrophin gel on 1982-01-01. It is used to treat collagen diseases, erythema multiforme, infantile spasms, multiple sclerosis, and nephrotic syndrome amongst others in the USA. The pharmaceutical is active against adrenocorticotropic hormone receptor. In addition, it is known to target CRHR1-IT1-CRHR1 protein, melanocortin receptor 5, melanocortin receptor 4, melanocyte-stimulating hormone receptor, melanocortin receptor 3, and corticotropin-releasing factor receptor 2.
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Commercial
Trade Name
FDA
EMA
Acthar, Cortrophin (discontinued: Acth)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acthar | New Drug Application | 2021-03-11 |
| purified cortrophin gel | New Drug Application | 2021-11-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| collagen diseases | — | D003095 | — |
| erythema multiforme | — | D004892 | L51 |
| infantile spasms | EFO_1000643 | D013036 | G40.82 |
| multiple sclerosis | EFO_0003885 | D009103 | G35 |
| nephrotic syndrome | EFO_0004255 | D009404 | N04 |
| optic neuritis | EFO_0007405 | D009902 | H46 |
| rheumatic diseases | — | D012216 | M79.0 |
| sarcoidosis | EFO_0000690 | D012507 | D80-D89 |
| serum sickness | — | D012713 | T80.6 |
| uveitis | EFO_1001231 | D014605 | H20.9 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0800 | Injection, corticotropin, up to 40 units |
Clinical
Clinical Trials
209 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | G89.18 | 2 | 4 | 1 | 9 | 2 | 16 | |
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | 3 | — | 6 | 1 | 13 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | 5 | 3 | 2 | 2 | 12 |
| Neonatal abstinence syndrome | D009357 | EFO_0005799 | P96.1 | — | 3 | 2 | 3 | 1 | 8 |
| Delirium | D003693 | R41.0 | — | 1 | 2 | 4 | — | 7 | |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | 3 | 2 | — | 6 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 2 | 2 | — | 1 | 1 | 5 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 2 | 2 | 4 |
| Labor pain | D048949 | — | — | — | 3 | 1 | 4 | ||
| Critical illness | D016638 | — | — | 2 | 2 | — | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 4 | 1 | — | — | 5 | |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | 2 | 1 | — | — | 3 |
| Hyperalgesia | D006930 | — | — | 1 | — | 1 | 2 | ||
| Neoplasms | D009369 | C80 | 1 | — | 1 | — | — | 2 | |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | — | 2 | — | — | 2 |
| Fecal incontinence | D005242 | R15 | — | 1 | 1 | — | — | 2 | |
| Emergence delirium | D000071257 | — | 1 | 1 | — | 1 | 2 | ||
| Pain management | D059408 | — | — | 1 | — | 1 | 2 | ||
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | 1 | — | — | 2 |
| Epidural anesthesia | D000767 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 3 | 1 | — | — | — | 4 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Orthostatic intolerance | D054971 | 2 | 1 | — | — | — | 2 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | — | — | 2 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 1 | — | — | 1 | 2 |
| Anesthesia | D000758 | — | 2 | — | — | — | 2 | ||
| Back pain | D001416 | HP_0003418 | M54 | — | 1 | — | — | 1 | 2 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | 1 | — | — | 1 | 2 |
| Conduction anesthesia | D000765 | — | 1 | — | — | — | 1 | ||
| Herniorrhaphy | D059685 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | D001794 | EFO_0004325 | 2 | — | — | — | — | 2 | |
| Male circumcision | D002944 | EFO_0003953 | 1 | — | — | — | — | 1 | |
| Vascular stiffness | D059289 | 1 | — | — | — | — | 1 | ||
| Neurodegenerative diseases | D019636 | EFO_0005772 | G31.9 | 1 | — | — | — | — | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | I95.1 | 1 | — | — | — | — | 1 | |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | 1 | — | — | — | — | 1 |
| Mood disorders | D019964 | EFO_0004247 | F30-F39 | 1 | — | — | — | — | 1 |
| Cocaine-related disorders | D019970 | F14 | 1 | — | — | — | — | 1 | |
| Heroin dependence | D006556 | EFO_0004240 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Pilonidal sinus | D010864 | HP_0010769 | L05 | — | — | — | — | 1 | 1 |
| Rhytidoplasty | D015361 | — | — | — | — | 1 | 1 | ||
| Asphyxia neonatorum | D001238 | EFO_1000824 | P84 | — | — | — | — | 1 | 1 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | — | — | — | 1 | 1 | |
| Radiculopathy | D011843 | M54.1 | — | — | — | — | 1 | 1 | |
| Ventricular tachycardia | D017180 | I47.2 | — | — | — | — | 1 | 1 | |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | — | — | 1 | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CORTICOTROPIN |
| INN | corticotropin |
| Description | Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency. It has a role as a diagnostic agent. It is a polypeptide, a peptide hormone and a biomacromolecule. |
| Classification | Protein |
| Drug class | atropine derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 9002-60-2 |
| RxCUI | 376 |
| ChEMBL ID | CHEMBL1201610 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB01285 |
| UNII ID | K0U68Q2TXA (ChemIDplus, GSRS) |
Target
Agency Approved
MC2R
MC2R
Organism
Homo sapiens
Gene name
MC2R
Gene synonyms
ACTHR
NCBI Gene ID
Protein name
adrenocorticotropic hormone receptor
Protein synonyms
ACTH receptor, Adrenocorticotropin receptor, corticotropin receptor, MC2 receptor, MC2-R, melanocortin 2 receptor (adrenocorticotropic hormone), Melanocortin receptor 2
Uniprot ID
Mouse ortholog
Mc2r (17200)
adrenocorticotropic hormone receptor (Q64326)
Alternate
LINC02210-CRHR1
LINC02210-CRHR1
MC5R
MC5R
MC4R
MC4R
MC1R
MC1R
MC3R
MC3R
CRHR2
CRHR2
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 35,785 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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14,079 adverse events reported
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