Crenezumab
Crenezumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against amyloid-beta precursor protein.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 5 | 3 | — | — | 9 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 2 | — | — | — | — | 2 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CRENEZUMAB |
| INN | crenezumab |
| Description | Crenezumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >5VZY:H|Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain
EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYGMSWVRQAPGKGLELVASINSNGGSTYYPDSVKGRFTISRDNAKNSLY
LQMNSLRAEDTAVYYCASGDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTS
GVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT
>5VZY:L|Crenezumab Fab light chain,Immunoblobulin light chain
DIVMTQSPLSLPVTPGEPASISCRSSQSLVYSNGDTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKI
SRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 5VZX, 5VZY |
| CAS-ID | 1095207-05-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743004 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11959 |
| UNII ID | O8AS5277H0 (ChemIDplus, GSRS) |
Target
Agency Approved
APP
APP
Organism
Homo sapiens
Gene name
APP
Gene synonyms
A4, AD1
NCBI Gene ID
Protein name
amyloid-beta precursor protein
Protein synonyms
ABPP, Alzheimer disease amyloid A4 protein homolog, Alzheimer disease amyloid protein, amyloid beta (A4) precursor protein, amyloid beta A4 protein, Amyloid precursor protein, Amyloid-beta (A4) precursor protein, Amyloid-beta A4 protein, APPI, beta-amyloid peptide, beta-amyloid peptide(1-40), beta-amyloid peptide(1-42), beta-amyloid precursor protein, Cerebral vascular amyloid peptide, CVAP, peptidase nexin-II, PN-II, PreA4, Protease nexin-II, testicular tissue protein Li 2
Uniprot ID
Mouse ortholog
App (11820)
amyloid-beta precursor protein (Q99K32)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 504 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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