Cyclopentolate
Ak-pentolate, Pentolair (cyclopentolate) is a small molecule pharmaceutical. Cyclopentolate was first approved as Ak-pentolate on 1982-01-01.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ak-pentolate | ANDA | 2010-09-01 |
| cyclogyl | ANDA | 2020-12-21 |
| cyclomydril | ANDA | 2020-12-19 |
| cyclopentolate hydrochloride | ANDA | 2022-09-29 |
Indications
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EMA
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Agency Specific
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
193 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | 2 | 2 | 2 | 3 | 15 | 22 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 3 | 2 | 4 | 5 | 12 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 1 | 2 | — | 5 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 2 | 1 | 2 | 5 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 2 | 1 | — | 4 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | 1 | 2 | 1 | 4 |
| Neoplasms | D009369 | C80 | — | — | 1 | 2 | — | 3 | |
| Vasoplegia | D056987 | — | 2 | — | 1 | — | 3 | ||
| Cognitive dysfunction | D060825 | G31.84 | 1 | — | — | 1 | 1 | 3 | |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | — | — | — | 1 | 2 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | 1 | 8 | 5 | — | 1 | 13 | ||
| Coronary artery disease | D003324 | I25.1 | — | 2 | 1 | — | 1 | 4 | |
| T-cell lymphoma peripheral | D016411 | C84.9 | 2 | 3 | 1 | — | — | 4 | |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | 2 | 2 | — | 2 | 4 |
| Covid-19 | D000086382 | U07.1 | — | 1 | 1 | — | 1 | 3 | |
| Lung neoplasms | D008175 | C34.90 | — | 3 | 1 | — | — | 3 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | 1 | — | 2 | 3 |
| Urinary bladder neoplasms | D001749 | C67 | — | 1 | 1 | — | — | 2 | |
| Transitional cell carcinoma | D002295 | — | 1 | 1 | — | — | 2 | ||
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | — | 1 | — | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | 1 | — | — | 4 | 5 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | 1 | 4 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | 1 | — | — | 1 | 2 |
| Head and neck neoplasms | D006258 | — | 2 | — | — | — | 2 | ||
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | 2 | — | — | — | 2 |
| Nasopharyngeal neoplasms | D009303 | — | 2 | — | — | — | 2 | ||
| B-cell lymphoma | D016393 | 1 | 2 | — | — | — | 2 | ||
| Coronary disease | D003327 | — | 1 | — | — | — | 1 | ||
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | 1 | — | — | — | 2 | 3 |
| T-cell lymphoma cutaneous | D016410 | C84.A | 2 | — | — | — | — | 2 | |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Pancreatic ductal carcinoma | D021441 | 1 | — | — | — | — | 1 | ||
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | 1 | — | — | — | — | 1 | ||
| Adenocarcinoma | D000230 | 1 | — | — | — | — | 1 | ||
| Sezary syndrome | D012751 | C84.1 | 1 | — | — | — | — | 1 | |
| Primary cutaneous anaplastic large cell lymphoma | D054446 | C86.6 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | 3 | 3 | ||
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 2 | 2 |
| Hyperhomocysteinemia | D020138 | — | — | — | — | 2 | 2 | ||
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | — | — | 2 | 2 |
| Aphthous stomatitis | D013281 | EFO_0003938 | K12.0 | — | — | — | — | 2 | 2 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 2 | 2 |
| Diabetes complications | D048909 | — | — | — | — | 1 | 1 | ||
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | 1 | 1 | |
| Delirium | D003693 | R41.0 | — | — | — | — | 1 | 1 | |
| Neutropenia | D009503 | D70 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CYCLOPENTOLATE |
| INN | cyclopentolate |
| Description | Cyclopentolate is a carboxylic ester resulting from the formal condensation of (1-hydroxycyclopentyl)(phenyl)acetic acid with N,N-dimethylethanolamine. A tertiary amine antimuscarinic with actions similar to atropine, it is used as its hydrochloride salt to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action. It has a role as a mydriatic agent, a parasympatholytic, a muscarinic antagonist and a diagnostic agent. It is a carboxylic ester, a tertiary amino compound and a tertiary alcohol. It is functionally related to a (1-hydroxycyclopentyl)phenylacetic acid and a N,N-dimethylethanolamine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCOC(=O)C(c1ccccc1)C1(O)CCCC1 |
Identifiers
| PDB | — |
| CAS-ID | 512-15-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201338 |
| ChEBI ID | 4024 |
| PubChem CID | 2905 |
| DrugBank | DB00979 |
| UNII ID | I76F4SHP7J (ChemIDplus, GSRS) |
Target
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Alternate
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Variants
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Safety
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Adverse Events
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3,308 adverse events reported
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