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Cyclophosphamide
Cytoxan, Neosar (cyclophosphamide) is a small molecule pharmaceutical. Cyclophosphamide was first approved as Cytoxan on 1982-01-01. It is used to treat b-cell chronic lymphocytic leukemia, BCR-ABL positive chronic myelogenous leukemia, breast neoplasms, burkitt lymphoma, and endometrial neoplasms amongst others in the USA.
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Drugs Approved for Childhood Cancers
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
neoplasmsD009369
musculoskeletal diseasesD009140
respiratory tract diseasesD012140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
cardiovascular diseasesD002318
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
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Trade Name
FDA
EMA
Cytoxan (generic drugs available since 2008-05-21, discontinued: Cytoxan (lyophilized), Lyophilized cytoxan, Neosar)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cyclophosphamide
Tradename
Company
Number
Date
Products
CYTOXANBaxterN-012141 RX1982-01-01
2 products, RLD
CYCLOPHOSPHAMIDEEugia Pharma SpecialtiesN-210735 RX2021-08-25
2 products, RLD, RS
CYCLOPHOSPHAMIDEHikma PharmaceuticalsN-203856 RX2013-09-16
2 products, RLD, RS
CYCLOPHOSPHAMIDEIngenusN-212501 RX2020-07-30
3 products, RLD, RS
Show 6 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
cyclophosphamideANDA2022-07-31
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
b-cell chronic lymphocytic leukemiaD015451C91.1
bcr-abl positive chronic myelogenous leukemiaEFO_0000340D015464
breast neoplasmsEFO_0003869D001943C50
burkitt lymphomaD002051C83.7
endometrial neoplasmsEFO_0004230D016889
ewing sarcomaEFO_0000173D012512
granulomatosis with polyangiitisEFO_0005297D014890M31.3
hemolytic anemia autoimmuneEFO_1001264D000744D59.10
hemosiderosisD006486
hodgkin diseaseD006689C81
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Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Cyclophosphamide, Cyclophosphamide, Ingenus Pharms Llc
109939522036-02-15DP
Cyclophosphamide, Cyclophosphamide, Eugia Pharma Speclts
96623422035-06-26DP
ATC Codes
L: Antineoplastic and immunomodulating agents
L01: Antineoplastic agents
L01A: Alkylating agents
L01AA: Nitrogen mustard analogues
L01AA01: Cyclophosphamide
HCPCS
Code
Description
C9087
Injection, cyclophosphamide, (auromedics), 10 mg
J8530
Cyclophosphamide; oral, 25 mg
J9070
Cyclophosphamide, 100 mg
Clinical
Clinical Trials
3120 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50792721541342510
LymphomaD008223C85.97122957224351
LeukemiaD007938C955918249120281
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.087150421413265
Multiple myelomaD009101C90.0791292527212
Myelodysplastic syndromesD009190D466314217215211
Non-hodgkin lymphomaD008228C85.97610912210177
B-cell chronic lymphocytic leukemiaD015451C91.148881634142
Large b-cell lymphoma diffuseD016403C83.359832523141
Plasma cell neoplasmsD054219135261777
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.061101199168
NeoplasmsD009369C80956765141
MelanomaD008545626512106
NeuroblastomaD009447EFO_0000621373719593
Hodgkin diseaseD006689C81236013791
Ovarian neoplasmsD010051EFO_0003893C5641455276
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_000034018595475
Triple negative breast neoplasmsD064726225011170
B-cell lymphomaD01639341273265
SarcomaD012509242712159
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C252127338
Colorectal neoplasmsD0151791617126
Fallopian tube neoplasmsD0051851512125
B-cell lymphoma marginal zoneD018442C88.4713220
Myeloid leukemia chronic-phaseD01546651518
Prostatic neoplasmsD011471C6114718
OsteosarcomaD01251611515
Stomach neoplasmsD013274EFO_0003897C1613814
Prolymphocytic leukemiaD015463311114
Skin neoplasmsD012878EFO_0004198C4431213
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Primitive neuroectodermal tumorsD018242213
Clear cell sarcomaD01822733
HepatoblastomaD018197C22.233
LiposarcomaD00808033
Myasthenia gravisD009157EFO_0004991G70.022
Endodermal sinus tumorD01824022
Adrenocortical carcinomaD01826822
NauseaD009325HP_0002018R11.011
PinealomaD01087111
Deltaretrovirus infectionsD006800EFO_100130311
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chediak-higashi syndromeD002609Orphanet_167D72.033
Hemoglobin sc diseaseD006450EFO_1001797D57.222
Cognitive dysfunctionD060825G31.8422
Pure red-cell aplasiaD012010HP_001241022
Trophoblastic neoplasmsD01432811
FatigueD005221HP_0012378R53.8311
Ataxia telangiectasiaD001260Orphanet_100G11.311
Hyper-igm immunodeficiency syndromeD053306Orphanet_101088D80.511
ProteinuriaD011507HP_0000093R8011
OtotoxicityD00008101511
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCYCLOPHOSPHAMIDE
INNcyclophosphamide
Description
Cyclophosphamide is a phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom. It has a role as a carcinogenic agent, an alkylating agent, an immunosuppressive agent, an antineoplastic agent, an antirheumatic drug, an environmental contaminant, a xenobiotic and a drug allergen. It is a phosphorodiamide, a nitrogen mustard and an organochlorine compound.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O.O=P1(N(CCCl)CCCl)NCCCO1
Identifiers
PDB
CAS-ID6055-19-2
RxCUI
ChEMBL IDCHEMBL1200796
ChEBI ID4026
PubChem CID2907
DrugBankDB00531
UNII ID6UXW23996M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 118,463 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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