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Cyclothiazide
Anhydron, Fluidil (cyclothiazide) is a small molecule pharmaceutical. Cyclothiazide was first approved as Anhydron on 1982-01-01. It is used to treat edema, heart failure, hypertension, and nephrotic syndrome in the USA. The pharmaceutical is active against solute carrier family 12 member 3. In addition, it is known to target glutamate receptor 1, glutamate receptor 3, glutamate receptor 4, and glutamate receptor 2.
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Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cyclothiazide
Tradename
Company
Number
Date
Products
ANHYDRONEli LillyN-013157 DISCN1982-01-01
1 products
FLUIDILPharmacia & UpjohnN-018173 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
edema—D004487R60.9
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
nephrotic syndromeEFO_0004255D009404N04
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03A: Low-ceiling diuretics, thiazides
— C03AA: Thiazides, plain
— C03AA09: Cyclothiazide
— C03AB: Thiazides and potassium in combination
— C03AB09: Cyclothiazide and potassium
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCYCLOTHIAZIDE
INNcyclothiazide
Description
Cyclothiazide is 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema. It has a role as a diuretic and an antihypertensive agent.
Classification
Small molecule
Drug classdiuretics (thiazide derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O
Identifiers
PDB1LBC
CAS-ID2259-96-3
RxCUI22033
ChEMBL IDCHEMBL61593
ChEBI ID31448
PubChem CID2910
DrugBankDB00606
UNII IDP71U09G5BW (ChemIDplus, GSRS)
Target
Agency Approved
SLC12A3
SLC12A3
Organism
Homo sapiens
Gene name
SLC12A3
Gene synonyms
NCC, TSC
NCBI Gene ID
6559
Protein name
solute carrier family 12 member 3
Protein synonyms
Na-Cl cotransporter, Na-Cl symporter, NaCl electroneutral thiazide-sensitive cotransporter, NCC, sodium-chloride co-transporter, solute carrier family 12 (sodium/chloride transporter), member 3, thiazide-sensitive Na-Cl cotransporter, Thiazide-sensitive sodium-chloride cotransporter
Uniprot ID
P55017
Mouse ortholog
Slc12a3 (20497)
solute carrier family 12 member 3 (P59158)
Alternate
GRIA1
GRIA1
GRIA3
GRIA3
GRIA4
GRIA4
GRIA2
GRIA2
Organism
Homo sapiens
Gene name
GRIA1
Gene synonyms
GLUH1, GLUR1
NCBI Gene ID
2890
Protein name
glutamate receptor 1
Protein synonyms
AMPA 1, AMPA receptor subunit GluA1, AMPA-selective glutamate receptor 1, GluA1, gluR-1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, glutamate receptor, ionotropic, AMPA 1
Uniprot ID
Q2NKM6
Mouse ortholog
Gria1 (14799)
glutamate receptor 1 (P23818)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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