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Daglutril
Daglutril is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target neprilysin and endothelin-converting enzyme 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10—2———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDAGLUTRIL
INNdaglutril
Description
Daglutril is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target neprilysin and endothelin-converting enzyme 1.
Classification
Small molecule
Drug classendopeptidase inhibitors: neutral endopeptidase inhibitors possessing additional endothelin converting enzyme inhibitory activity
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)[C@H](CCCc1ccccc1)C1(C(=O)N[C@H]2CCc3ccccc3N(CC(=O)O)C2=O)CCCC1
Identifiers
PDB—
CAS-ID—
RxCUI—
ChEMBL IDCHEMBL3989794
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDKKV299446X (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MME
MME
ECE1
ECE1
Organism
Homo sapiens
Gene name
MME
Gene synonyms
EPN
NCBI Gene ID
4311
Protein name
neprilysin
Protein synonyms
Atriopeptidase, CALLA, CD10, Common acute lymphocytic leukemia antigen, Enkephalinase, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), NEP, neprilysin-390, neprilysin-411, Neutral endopeptidase, Neutral endopeptidase 24.11, SFE, Skin fibroblast elastase
Uniprot ID
Q3MIX4
Mouse ortholog
Mme (17380)
neprilysin (Q8K251)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 26 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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