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Danusertib
Danusertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against aurora kinase A, aurora kinase B, and aurora kinase C. In addition, it is known to target STE20-like serine/threonine-protein kinase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C95—1———1
Multiple myelomaD009101C90.0—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDANUSERTIB
INNdanusertib
Description
N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide is a member of piperazines.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1
Identifiers
PDB—
CAS-ID827318-97-8
RxCUI—
ChEMBL IDCHEMBL402548
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDM3X659D0FY (ChemIDplus, GSRS)
Target
Agency Approved
AURKA
AURKA
AURKB
AURKB
AURKC
AURKC
Organism
Homo sapiens
Gene name
AURKA
Gene synonyms
AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
NCBI Gene ID
6790
Protein name
aurora kinase A
Protein synonyms
ARK-1, Aurora 2, Aurora-related kinase 1, aurora/IPL1-like kinase, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Ipl1- and aurora-related kinase 1, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase Ayk1
Uniprot ID
Q9UPG5
Mouse ortholog
Aurka (20878)
aurora kinase A (Q91YU4)
Alternate
SLK
SLK
Organism
Homo sapiens
Gene name
SLK
Gene synonyms
KIAA0204, STK2
NCBI Gene ID
9748
Protein name
STE20-like serine/threonine-protein kinase
Protein synonyms
CTCL tumor antigen se20-9, hSLK, Long Ste20-like Kinase, Serine/threonine-protein kinase 2, SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase, SNF1 sucrose nonfermenting like kinase, STE20-related kinase, Ste20-related serine/threonine kinase, STE20-related serine/threonine-protein kinase
Uniprot ID
Q9H2G2
Mouse ortholog
Slk (20874)
STE20-like serine/threonine-protein kinase (O54988)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 392 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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