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Desipramine
Norpramin (desipramine) is a small molecule pharmaceutical. Desipramine was first approved as Pertofrane on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, depressive disorder, pain, psychotic affective disorders, and substance-related disorders in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target equilibrative nucleoside transporter 4, G protein-activated inward rectifier potassium channel 2, and G protein-activated inward rectifier potassium channel 4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Norpramin (generic drugs available since 1987-06-05, discontinued: Pertofrane)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desipramine hydrochloride
Tradename
Company
Number
Date
Products
NORPRAMINValidus PharmaceuticalsN-014399 RX1982-01-01
6 products, RLD
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
desipramine hydrochlorideANDA2023-05-17
norpraminNew Drug Application2021-01-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
attention deficit disorder with hyperactivityEFO_0003888D001289F90
depressive disorderEFO_1002014D003866F32.A
painEFO_0003843D010146R52
psychotic affective disorders—D000341F39
substance-related disordersEFO_0003890D019966F13
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AA: Non-selective monoamine reuptake inhibitors
— N06AA01: Desipramine
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.0———2—2
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Brain neoplasmsD001932EFO_0003833C711————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDESIPRAMINE
INNdesipramine
Description
Desipramine is a dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. It has a role as an adrenergic uptake inhibitor, a serotonin uptake inhibitor, a cholinergic antagonist, an alpha-adrenergic antagonist, a H1-receptor antagonist, an EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an antidepressant and a drug allergen. It is a dibenzoazepine and a secondary amino compound.
Classification
Small molecule
Drug classantidepressants (imipramine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNCCCN1c2ccccc2CCc2ccccc21
Identifiers
PDB2QB4
CAS-ID50-47-5
RxCUI3247
ChEMBL IDCHEMBL72
ChEBI ID47781
PubChem CID2995
DrugBankDB01151
UNII IDTG537D343B (ChemIDplus, GSRS)
Target
Agency Approved
SLC6A4
SLC6A4
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
6532
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Q5EE02
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
SLC29A4
SLC29A4
KCNJ6
KCNJ6
KCNJ5
KCNJ5
Organism
Homo sapiens
Gene name
SLC29A4
Gene synonyms
ENT4, PMAT
NCBI Gene ID
222962
Protein name
equilibrative nucleoside transporter 4
Protein synonyms
Plasma membrane monoamine transporter, PMAT, solute carrier family 29 (equilibrative nucleoside transporter), member 4, solute carrier family 29 (nucleoside transporters), member 4, Solute carrier family 29 member 4
Uniprot ID
Q8NBM2
Mouse ortholog
Slc29a4 (243328)
equilibrative nucleoside transporter 4 (Q8R139)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 9,967 documents
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Safety
Black-box Warning
Black-box warning for: Desipramine hydrochloride, Norpramin
Adverse Events
Top Adverse Reactions
Mock data
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96 adverse events reported
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