Desogestrel
Cyclessa (desogestrel) is a small molecule pharmaceutical. Desogestrel was first approved as Desogen on 1992-12-10. It is used to treat acne vulgaris, endometriosis, and menstruation disturbances in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
| skin and connective tissue diseases | D017437 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Combinations
Cyclessa (generic drugs available since 1999-08-12, discontinued: Desogen, Emoquette, Mircette, Ortho-cept)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desogestrel
+
Ethinyl estradiol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CYCLESSA | Aspen Global | N-021090 RX | 2000-12-20 | 1 products, RLD, RS |
Show 3 discontinued
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acne vulgaris | EFO_0003894 | D000152 | L70 |
| endometriosis | EFO_0001065 | D004715 | N80 |
| menstruation disturbances | HP_0400007 | D008599 | N91.5 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA09: Desogestrel and ethinylestradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB05: Desogestrel and ethinylestradiol
— G03AC: Progestogen systemic hormonal contraceptives
— G03AC09: Desogestrel
— G03F: Progestogens and estrogens in combination
— G03FB: Progestogens and estrogens, sequential preparations
— G03FB10: Desogestrel and estrogen
HCPCS
No data
Clinical
Clinical Trials
87 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nocturia | D053158 | R35.1 | — | 7 | 16 | 2 | 4 | 27 | |
| Nocturnal enuresis | D053206 | N39.44 | — | — | 3 | 7 | 4 | 14 | |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 1 | — | — | 2 | 2 | 5 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 1 | — | 2 | — | 4 |
| Hypothermia | D007035 | HP_0002045 | T68 | — | — | — | 1 | 1 | 2 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | 1 | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | 1 | 1 | 2 |
| Postoperative hemorrhage | D019106 | — | — | — | 2 | — | 2 | ||
| Cardiac surgical procedures | D006348 | — | — | — | 1 | — | 1 | ||
| Aortic valve stenosis | D001024 | EFO_0000266 | Q25.1 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal colic | D056844 | EFO_1001412 | N23 | — | — | 1 | — | 1 | 2 |
| Neurogenic diabetes insipidus | D020790 | HP_0000863 | — | — | 1 | — | 1 | 2 | |
| Leptospirosis | D007922 | EFO_0007344 | A27 | — | 1 | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | — | — | — | 2 |
| Cerebral hemorrhage | D002543 | — | 1 | — | — | — | 1 | ||
| Ecchymosis | D004438 | HP_0000978 | — | 1 | — | — | — | 1 | |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | — | 1 | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | 1 | — | — | — | 1 | ||
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | — | 1 |
| Dyspnea | D004417 | HP_0002094 | R06.0 | 1 | — | — | — | — | 1 |
| Tachycardia | D013610 | HP_0001649 | R00.0 | 1 | — | — | — | — | 1 |
| Prostatic neoplasms | D011471 | C61 | 1 | — | — | — | — | 1 | |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | — | — | — | — | 1 |
| Intracranial arteriosclerosis | D002537 | EFO_1000860 | I67.2 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes insipidus | D003919 | E23.2 | — | — | — | — | 2 | 2 | |
| Wounds and injuries | D014947 | T14.8 | — | — | — | — | 1 | 1 | |
| Hemodilution | D006438 | — | — | — | — | 1 | 1 | ||
| Menorrhagia | D008595 | N92.0 | — | — | — | — | 1 | 1 | |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | — | — | — | 1 | 1 |
| Blood platelet disorders | D001791 | — | — | — | — | 1 | 1 | ||
| Von willebrand diseases | D014842 | D68.0 | — | — | — | — | 1 | 1 | |
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | — | — | 1 | 1 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Nephrogenic diabetes insipidus | D018500 | N25.1 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DESOGESTREL |
| INN | desogestrel |
| Description | Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive. |
| Classification | Small molecule |
| Drug class | estrogens; progestins |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC |
Identifiers
| PDB | — |
| CAS-ID | 54024-22-5 |
| RxCUI | 22656 |
| ChEMBL ID | CHEMBL1533 |
| ChEBI ID | 4453 |
| PubChem CID | 40973 |
| DrugBank | DB00304 |
| UNII ID | 81K9V7M3A3 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Emoquette, Enskyce
, Isibloom, Kalliga, Volnea
Adverse Events
Top Adverse Reactions
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8,845 adverse events reported
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