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Dexfenfluramine
Dexfenfluramine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tryptophan 5-hydroxylase 2 and tryptophan 5-hydroxylase 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
obesityEFO_0001073D009765E66.9
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A08: Antiobesity preparations, excl. diet products
— A08A: Antiobesity preparations, excl. diet products
— A08AA: Centrally acting antiobesity products
— A08AA04: Dexfenfluramine
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Amphetamine-related disordersD019969EFO_0004701F15————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDEXFENFLURAMINE
INNdexfenfluramine
Description
(S)-fenfluramine is the S-enantiomer of fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike fenfluramine it does not possess catecholamine agonist activity. It was formerly given by mouth as the hydrochloride in the treatment of obesity, but, like fenfluramine, was withdrawn wolrdwide following reports of valvular heart defects. It has a role as an appetite depressant, a serotonergic agonist and a serotonin uptake inhibitor. It is an enantiomer of a (R)-fenfluramine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1
Identifiers
PDB—
CAS-ID3239-44-9
RxCUI3268
ChEMBL IDCHEMBL248702
ChEBI ID439329
PubChem CID66265
DrugBankDB01191
UNII IDE35R3G56OV (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TPH2
TPH2
TPH1
TPH1
Organism
Homo sapiens
Gene name
TPH2
Gene synonyms
NTPH
NCBI Gene ID
121278
Protein name
tryptophan 5-hydroxylase 2
Protein synonyms
Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2
Uniprot ID
Q8IWU9
Mouse ortholog
Tph2 (216343)
tryptophan 5-hydroxylase 2 (Q8CGV2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,076 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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