Skip to content
Diethylstilbestrol
Stilbestrol, Stilbetin, Stilphostrol (diethylstilbestrol) is a small molecule pharmaceutical. Diethylstilbestrol was first approved as Stilbestrol on 1982-01-01. It is used to treat breast neoplasms, carcinoma, and prostatic neoplasms in the USA. The pharmaceutical is active against estrogen receptor. In addition, it is known to target estrogen receptor beta, steroid hormone receptor ERR2, estrogen-related receptor gamma, and steroid hormone receptor ERR1.
Download report
Favorite
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Diethylstilbestrol
Tradename
Company
Number
Date
Products
STILBESTROLBristol Myers SquibbN-004056 DISCN1982-01-01
6 products
STILBETINBristol Myers SquibbN-004056 DISCN1982-01-01
9 products
DIETHYLSTILBESTROLEli LillyN-004039 DISCN1982-01-01
5 products
DIETHYLSTILBESTROLEli LillyN-004040 DISCN1982-01-01
2 products
DIETHYLSTILBESTROLEli LillyN-004041 DISCN1982-01-01
4 products
Hide discontinued
Diethylstilbestrol diphosphate
Tradename
Company
Number
Date
Products
STILPHOSTROLBayerN-010010 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
carcinoma—D002277C80.0
prostatic neoplasms—D011471C61
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03C: Estrogens, sex hormones and modulators of the genital system
— G03CB: Synthetic estrogens, plain
— G03CB02: Diethylstilbestrol
— G03CC: Estrogens, combinations with other drugs
— G03CC05: Diethylstilbestrol
L: Antineoplastic and immunomodulating agents
— L02: Endocrine therapy antineoplastic and immunomodulating agents
— L02A: Hormones and related agents
— L02AA: Estrogens, endocrine therapy drugs
— L02AA01: Diethylstilbestrol
HCPCS
Code
Description
J9165
Injection, diethylstilbestrol diphosphate, 250 mg
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameDIETHYLSTILBESTROL
INNdiethylstilbestrol
Description
Diethylstilbestrol is an olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups. It has a role as an antineoplastic agent, a carcinogenic agent, a xenoestrogen, an EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor, an antifungal agent, an endocrine disruptor, an EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor, an autophagy inducer and a calcium channel blocker. It is a polyphenol and an olefinic compound.
Classification
Small molecule
Drug classestrogens
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1
Identifiers
PDB4ZN7
CAS-ID56-53-1
RxCUI3390
ChEMBL IDCHEMBL411
ChEBI ID41922
PubChem CID448537
DrugBankDB00255
UNII ID731DCA35BT (ChemIDplus, GSRS)
Target
Agency Approved
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
2099
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Q9UIS7
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Alternate
ESR2
ESR2
ESRRB
ESRRB
ESRRG
ESRRG
ESRRA
ESRRA
Organism
Homo sapiens
Gene name
ESR2
Gene synonyms
ESTRB, NR3A2
NCBI Gene ID
2100
Protein name
estrogen receptor beta
Protein synonyms
estrogen receptor beta 2, estrogen receptor beta 4, Nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Uniprot ID
Q92731
Mouse ortholog
Esr2 (13983)
estrogen receptor beta (O08537)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 8,632 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
62 adverse events reported
View more details