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Difamilast
Difamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4D.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atopic dermatitisD003876EFO_0000274L20238——13
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIFAMILAST
INNdifamilast
Description
Difamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4D.
Classification
Small molecule
Drug classantiasthmatics/antiallergics (not acting primarily as antihistamines): type IV phosphodiesterase
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOc1ccccc1C(=O)NCc1coc(-c2ccc(OC(F)F)c(OC(C)C)c2)n1
Identifiers
PDB—
CAS-ID937782-05-3
RxCUI—
ChEMBL IDCHEMBL3989968
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDT3U32GLJ0F (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PDE4D
PDE4D
Organism
Homo sapiens
Gene name
PDE4D
Gene synonyms
DPDE3
NCBI Gene ID
5144
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Protein synonyms
cAMP-specific phosphodiesterase PDE4D6, DPDE3, PDE43, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila), testicular tissue protein Li 136
Uniprot ID
Q9HCX7
Mouse ortholog
Pde4d (238871)
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Q8CG05)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 21 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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