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Difluprednate
Durezol (difluprednate) is a small molecule pharmaceutical. Difluprednate was first approved as Durezol on 2008-06-23. The pharmaceutical is active against glucocorticoid receptor.
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Novartis Pharmaceuticals
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Durezol (generic drugs available since 2021-08-09)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Difluprednate
Tradename
Company
Number
Date
Products
DUREZOLNovartisN-022212 RX2008-06-23
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
difluprednate ophthalmic emulsionANDA2020-07-01
durezolNew Drug Application2022-07-11
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC19: Difluprednate
HCPCS
No data
Clinical
Clinical Trials
21 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CataractD002386EFO_0001059H26.9——23—5
Anterior uveitisD014606EFO_1000811—121—4
UveitisD014605EFO_1001231H20.9——21—3
Macular edemaD008269———1—1
Corneal edemaD015715EFO_1000879H18.20———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249—26——8
PanuveitisD015864EFO_1001082H44.11——2——2
KeratitisD007634H16——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352H04.12—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIFLUPREDNATE
INNdifluprednate
Description
Difluprednate is a corticosteroid hormone and a butyrate ester.
Classification
Small molecule
Drug classprednisone and prednisolone derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCC(=O)O[C@]1(C(=O)COC(C)=O)CC[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
Identifiers
PDB—
CAS-ID23674-86-4
RxCUI23043
ChEMBL IDCHEMBL1201749
ChEBI ID31485
PubChem CID443936
DrugBankDB06781
UNII IDS8A06QG2QE (ChemIDplus, GSRS)
Target
Agency Approved
NR3C1
NR3C1
Organism
Homo sapiens
Gene name
NR3C1
Gene synonyms
GRL
NCBI Gene ID
2908
Protein name
glucocorticoid receptor
Protein synonyms
Nuclear receptor subfamily 3 group C member 1, nuclear receptor subfamily 3 group C member 1 variant hGR-B(54), nuclear receptor subfamily 3 group C member 1 variant hGR-B(77), nuclear receptor subfamily 3 group C member 1 variant hGR-B(93), nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Uniprot ID
Q6N0A4
Mouse ortholog
Nr3c1 (14815)
glucocorticoid receptor (Q61629)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 434 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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38,767 adverse events reported
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