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Dinoprost tromethamine
Prostin (dinoprost tromethamine) is a small molecule pharmaceutical. Dinoprost tromethamine was first approved as Prostin f2 alpha on 1982-01-01. It is known to target prostaglandin E2 receptor EP1 subtype, thromboxane A2 receptor, prostaglandin D2 receptor, prostaglandin F2-alpha receptor, prostaglandin E2 receptor EP4 subtype, prostaglandin E2 receptor EP3 subtype, prostaglandin D2 receptor 2, and prostaglandin E2 receptor EP2 subtype.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dinoprost tromethamine
Tradename
Company
Number
Date
Products
PROSTIN F2 ALPHAPharmacia & UpjohnN-017434 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
alprostadilANDA2020-02-29
prostin New Drug Application2022-10-03
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02A: Uterotonics
— G02AD: Prostaglandins, oxytocics
— G02AD01: Dinoprost
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B20———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Familial amyloid neuropathiesD028227E85.1—11——1
Familial amyloidosisD028226—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AmyloidosisD000686EFO_1001875E85————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDINOPROST TROMETHAMINE
INNalprostadil
Description
Prostaglandin F2alpha is a prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor. It has a role as a human metabolite and a mouse metabolite. It is a prostaglandins Falpha and a monocarboxylic acid. It is a conjugate acid of a prostaglandin F2alpha(1-).
Classification
Small molecule
Drug classprostaglandins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O.NC(CO)(CO)CO
Identifiers
PDB—
CAS-ID551-11-1
RxCUI3477
ChEMBL IDCHEMBL1200896
ChEBI ID31502
PubChem CID5280363
DrugBankDB12789
UNII IDF5TD010360 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PTGER1
PTGER1
TBXA2R
TBXA2R
PTGDR
PTGDR
PTGFR
PTGFR
PTGER4
PTGER4
PTGER3
PTGER3
PTGDR2
PTGDR2
PTGER2
PTGER2
Organism
Homo sapiens
Gene name
PTGER1
Gene synonyms
NCBI Gene ID
5731
Protein name
prostaglandin E2 receptor EP1 subtype
Protein synonyms
PGE receptor, EP1 subtype, PGE2 receptor EP1 subtype, prostaglandin E receptor 1 (subtype EP1), 42kD, prostaglandin E receptor 1 (subtype EP1), 42kDa, prostaglandin E receptor 1, subtype EP1, Prostanoid EP1 receptor
Uniprot ID
Q8NHB2
Mouse ortholog
Ptger1 (19216)
prostaglandin E2 receptor EP1 subtype (P35375)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,425 documents
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Safety
Black-box Warning
Black-box warning for: Alprostadil, Prostin
Adverse Events
Top Adverse Reactions
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133 adverse events reported
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