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Diphenoxylate
Lomotil (diphenoxylate) is a small molecule pharmaceutical. Diphenoxylate was first approved as Lomotil on 1982-01-01. It is used to treat diarrhea in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Combinations
Lomotil (generic drugs available since 1982-01-01, discontinued: Colonaid, Di-atro, Lo-trol, Logen, Lomanate, Lonox, Low-quel)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atropine sulfate
+
Diphenoxylate hydrochloride
Tradename
Company
Number
Date
Products
LOMOTILMylanN-012462 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
diphenoxylate hydrochloride and atropine sulfateANDA2023-06-13
lomotilNew Drug Application2022-04-01
sore throat logenzesOTC monograph not final2021-11-10
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diarrheaHP_0002014D003967R19.7
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07D: Antipropulsives
— A07DA: Antipropulsives
— A07DA01: Diphenoxylate
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VertigoD014717H81.39———1—1
Meniere diseaseD008575EFO_0006862H81.0———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDIPHENOXYLATE
INNdiphenoxylate
Description
Diphenoxylate is a piperidinecarboxylate ester that is the ethyl ester of difenoxin. It has a role as an antidiarrhoeal drug. It is a nitrile, a piperidinecarboxylate ester, a tertiary amine and an ethyl ester. It is functionally related to a difenoxin.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)C1(c2ccccc2)CCN(CCC(C#N)(c2ccccc2)c2ccccc2)CC1
Identifiers
PDB—
CAS-ID915-30-0
RxCUI3500
ChEMBL IDCHEMBL1201294
ChEBI ID4639
PubChem CID13505
DrugBankDB01081
UNII ID73312P173G (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,714 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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35 adverse events reported
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