Dipraglurant
Dipraglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target metabotropic glutamate receptor 5.
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 3 | 2 | — | — | 3 |
| Dyskinesias | D020820 | G24 | — | 2 | 2 | — | — | 2 | |
| Drug-induced dyskinesia | D004409 | EFO_1000904 | — | 2 | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dystonia | D004421 | HP_0001332 | G24 | — | 1 | — | — | — | 1 |
| Blepharospasm | D001764 | G24.5 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DIPRAGLURANT |
| INN | dipraglurant |
| Description | Dipraglurant (INN) (code name ADX-48621) is a negative allosteric modulator of the mGlu5 receptor which is under development by Addex Therapeutics for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID). As of 2014, it is in phase II clinical trials for this indication. Addex Therapeutics is also investigating an extended-release formulation of dipraglurant for the treatment of non-parkinsonian dystonia.
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| Classification | Small molecule |
| Drug class | metabotropic glutamate receptor antagonists, negative allosteric modulators |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1 |
Identifiers
| PDB | — |
| CAS-ID | 872363-17-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2346738 |
| ChEBI ID | — |
| PubChem CID | 44557636 |
| DrugBank | DB12733 |
| UNII ID | CV8JZR21A1 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
GRM5
GRM5
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Safety
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