Skip to content
Diquafosol
Diquafosol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target P2Y purinoceptor 4 and P2Y purinoceptor 2.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352H04.121361818
AsthenopiaD001248H53.14———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Keratoconjunctivitis siccaD007638EFO_1000906——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Photorefractive keratectomyD018903—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Meibomian gland dysfunctionD000080343H02.88————11
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameDIQUAFOSOL
INNdiquafosol
Description
P(1),P(4)-bis(uridin-5'-yl) tetraphosphate is a pyrimidine ribonucleoside 5'-tetraphosphate compound having 5'-uridinyl residues at the P(1)- and P(4)-positions. It has a role as a P2Y2 receptor agonist and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-tetraphosphate and a uridine 5'-phosphate.
Classification
Small molecule
Drug classphosphoro-derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(=O)[nH]c4=O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c(=O)[nH]1
Identifiers
PDB—
CAS-ID59985-21-6
RxCUI—
ChEMBL IDCHEMBL221326
ChEBI ID27791
PubChem CID148197
DrugBankDB15919
UNII ID7828VC80FJ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RY4
P2RY4
P2RY2
P2RY2
Organism
Homo sapiens
Gene name
P2RY4
Gene synonyms
NRU
NCBI Gene ID
5030
Protein name
P2Y purinoceptor 4
Protein synonyms
P2P, pyrimidinergic receptor P2Y, G-protein coupled, 4, UNR, Uridine nucleotide receptor
Uniprot ID
Q5JT22
Mouse ortholog
P2ry4 (57385)
P2Y purinoceptor 4 (Q9JJS7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 437 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
14 adverse events reported
View more details