Domperidone
Domperidone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor.
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Clinical
Clinical Trials
57 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | 1 | 2 | 1 | 13 | 17 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | 3 | 4 | 5 | 12 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | 2 | — | 1 | 1 | 5 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 2 | 2 | 1 | 5 |
| Healthy volunteers/patients | — | 2 | — | — | 1 | — | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | 2 | — | 1 | 3 |
| Digestive system diseases | D004066 | EFO_0000405 | K92.9 | — | — | 1 | — | 1 | 2 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | — | — | 2 | — | — | 2 |
| Esophagitis | D004941 | HP_0100633 | K20 | — | — | 1 | — | 1 | 2 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | 1 | — | — | 1 |
| Heartburn | D006356 | R12 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | 1 | — | — | — | 1 | |
| Chronic progressive multiple sclerosis | D020528 | — | 1 | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Esophageal achalasia | D004931 | HP_0002571 | K22.0 | — | — | — | — | 1 | 1 |
| Abdominal pain | D015746 | R10.9 | — | — | — | — | 1 | 1 | |
| Ventricular tachycardia | D017180 | I47.2 | — | — | — | — | 1 | 1 | |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | — | 1 | 1 | |
| Lactation | D007774 | — | — | — | — | 1 | 1 | ||
| Capsule endoscopy | D053704 | — | — | — | — | 1 | 1 | ||
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DOMPERIDONE |
| INN | domperidone |
| Description | Domperidone is 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations. It has a role as an antiemetic and a dopaminergic antagonist. It is a member of benzimidazoles and a heteroarylpiperidine. |
| Classification | Small molecule |
| Drug class | antipsychotics (risperidone type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]c2ccccc2n1CCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 57808-66-9 |
| RxCUI | 3626 |
| ChEMBL ID | CHEMBL219916 |
| ChEBI ID | 31515 |
| PubChem CID | 3151 |
| DrugBank | DB01184 |
| UNII ID | 5587267Z69 (ChemIDplus, GSRS) |
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,527 adverse events reported
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