Droperidol
Inapsine, Innovar (droperidol) is a small molecule pharmaceutical. Droperidol was first approved as Inapsine on 1982-01-01. It is used to treat pain and psychotic disorders in the USA.
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Commercial
Trade Name
FDA
EMA
Inapsine (generic drugs available since 1988-02-29)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| droperidol | ANDA | 2019-10-29 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
| psychotic disorders | — | D011618 | F20.81 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
Clinical
Clinical Trials
316 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acne vulgaris | D000152 | EFO_0003894 | L70 | 3 | 6 | 4 | 8 | 1 | 19 |
| Rosacea | D012393 | L71 | 3 | 1 | 4 | 8 | 1 | 17 | |
| Covid-19 | D000086382 | U07.1 | 1 | 3 | 5 | 3 | 2 | 13 | |
| Infections | D007239 | EFO_0000544 | — | — | — | 6 | 4 | 10 | |
| Periodontal diseases | D010510 | K05.6 | — | 3 | 2 | 2 | 3 | 9 | |
| Chlamydia infections | D002690 | EFO_0007205 | A74.9 | — | 1 | 2 | 5 | — | 8 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 2 | 3 | 1 | 6 |
| Syphilis | D013587 | EFO_0007504 | A53.9 | — | — | 2 | 4 | — | 6 |
| Lyme disease | D008193 | A69.2 | — | — | 2 | 2 | 1 | 5 | |
| Erythema chronicum migrans | D015787 | A26.0 | — | — | — | 1 | 4 | 5 |
Show 51 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | 3 | 1 | — | 1 | 4 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 3 | 2 | — | — | 4 |
| Graves ophthalmopathy | D049970 | EFO_1001466 | 1 | 3 | 1 | — | 1 | 4 | |
| Filarial elephantiasis | D004605 | EFO_0007272 | B74.0 | — | — | 3 | — | — | 3 |
| Lymphedema | D008209 | Q82.0 | — | — | 3 | — | — | 3 | |
| Filariasis | D005368 | B74 | — | — | 3 | — | — | 3 | |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 2 | 1 | — | — | 3 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 1 | 1 | — | — | 2 |
| Ventricular remodeling | D020257 | — | 1 | 1 | — | — | 2 | ||
| St elevation myocardial infarction | D000072657 | — | 1 | 1 | — | — | 2 |
Show 22 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | 2 | — | — | 1 | 3 | ||
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 2 | — | — | 1 | 3 |
| Pelvic inflammatory disease | D000292 | EFO_1001388 | N70-N77 | — | 1 | — | — | 1 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | 1 | — | — | 1 | 2 | ||
| Anthrax | D000881 | A22 | 1 | 1 | — | — | — | 2 | |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | 1 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 2 |
| T-cell lymphoma cutaneous | D016410 | C84.A | 1 | 1 | — | — | — | 2 | |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 2 | — | — | — | 2 |
| Mansonelliasis | D008368 | EFO_0007357 | B74.4 | — | 2 | — | — | — | 2 |
Show 57 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 6 | — | — | — | 2 | 8 | ||
| Therapeutic equivalency | D013810 | 5 | — | — | — | — | 5 | ||
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | 1 | — | — | — | 1 | 2 |
| Arteriovenous malformations | D001165 | 2 | — | — | — | — | 2 | ||
| Elbow tendinopathy | D000070639 | M77.0 | 1 | — | — | — | — | 1 | |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 1 | — | — | — | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | 1 | — | — | — | — | 1 | |
| Cardio-renal syndrome | D059347 | 1 | — | — | — | — | 1 | ||
| Intracranial aneurysm | D002532 | EFO_0003870 | I67.1 | 1 | — | — | — | — | 1 |
| Cavernous hemangioma | D006392 | D18.0 | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tick-borne encephalitis | D004675 | EFO_1001309 | A84 | — | — | — | — | 2 | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 2 | 2 |
| Malaria | D008288 | EFO_0001068 | B54 | — | — | — | — | 1 | 1 |
| Mycoplasma pneumonia | D011019 | EFO_0007387 | J15.7 | — | — | — | — | 1 | 1 |
| Aseptic meningitis | D008582 | EFO_1000823 | G03.0 | — | — | — | — | 1 | 1 |
| Staphylococcus aureus | D013211 | NCBITaxon_1280 | — | — | — | — | 1 | 1 | |
| Female infertility | D007247 | EFO_0008560 | N97 | — | — | — | — | 1 | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 1 | 1 |
| Infertility | D007246 | EFO_0000545 | — | — | — | — | 1 | 1 | |
| Diet therapy | D004035 | — | — | — | — | 1 | 1 |
Show 23 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DROPERIDOL |
| INN | droperidol |
| Description | Droperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It has a role as an antiemetic, a dopaminergic antagonist, a first generation antipsychotic and an anaesthesia adjuvant. It is a member of benzimidazoles, an organofluorine compound and an aromatic ketone. |
| Classification | Small molecule |
| Drug class | antipsychotics (haloperidol type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 548-73-2 |
| RxCUI | 3648 |
| ChEMBL ID | CHEMBL1108 |
| ChEBI ID | 4717 |
| PubChem CID | 3168 |
| DrugBank | DB00450 |
| UNII ID | O9U0F09D5X (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
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Financial
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Trends
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Safety
Black-box Warning
Black-box warning for: Droperidol
Adverse Events
Top Adverse Reactions
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21,334 adverse events reported
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