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Duvoglustat
Duvoglustat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target lysosomal alpha-glucosidase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Glycogen storage disease type iiD006009Orphanet_365E74.02—2———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDUVOGLUSTAT
INNduvoglustat
Description
Duvoglustat is an optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an anti-HIV agent, an anti-obesity agent, a bacterial metabolite, a hypoglycemic agent, a hepatoprotective agent and a plant metabolite. It is a 2-(hydroxymethyl)piperidine-3,4,5-triol and a piperidine alkaloid.
Classification
Small molecule
Drug classenzyme inhibitors: glucosyltransferase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Identifiers
PDB5DKY
CAS-ID19130-96-2
RxCUI—
ChEMBL IDCHEMBL307429
ChEBI ID44369
PubChem CID29435
DrugBankDB03206
UNII IDFZ56898FLE (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GAA
GAA
Organism
Homo sapiens
Gene name
GAA
Gene synonyms
NCBI Gene ID
2548
Protein name
lysosomal alpha-glucosidase
Protein synonyms
Acid maltase, Aglucosidase alfa, glucosidase alpha, acid
Uniprot ID
Q8IWE7
Mouse ortholog
Gaa (14387)
lysosomal alpha-glucosidase (Q91Z45)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 30 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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