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Ebselen
Ebselen is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target ORF1a polyprotein;ORF1ab polyprotein.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Meniere diseaseD008575EFO_0006862H81.01213
Type 2 diabetes mellitusD003924EFO_0001360E11111
Type 1 diabetes mellitusD003922EFO_0001359E10111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OtotoxicityD00008101522
Covid-19D000086382U07.122
Coronavirus infectionsD018352EFO_0007224B34.222
CoronavirusD01793422
Hearing lossD034381EFO_0004238H91.9112
Bipolar disorderD001714EFO_0000289F30.911
Noise-induced hearing lossD006317EFO_100125411
Head and neck neoplasmsD00625811
Lung neoplasmsD008175C34.9011
TinnitusD014012HP_0000360H93.111
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8011
Treatment-resistant depressive disorderD06121811
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEBSELEN
INNebselen
Description
Ebselen is a benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase. It has a role as a neuroprotective agent, an apoptosis inducer, an anti-inflammatory drug, an antioxidant, a hepatoprotective agent, a genotoxin, a radical scavenger, an enzyme mimic, an EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor, an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor, an EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor, an EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an EC 3.5.4.1 (cytosine deaminase) inhibitor, an EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor, a ferroptosis inhibitor, an antifungal agent, an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an anticoronaviral agent, an antibacterial agent, an antineoplastic agent and an EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=c1c2ccccc2[se]n1-c1ccccc1
Identifiers
PDB
CAS-ID60940-34-3
RxCUI
ChEMBL IDCHEMBL51085
ChEBI ID77543
PubChem CID3194
DrugBankDB12610
UNII ID40X2P7DPGH (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ORF1ab
ORF1ab
Organism
Severe acute respiratory syndrome coronavirus 2
Gene name
ORF1ab
Gene synonyms
NCBI Gene ID
Protein name
ORF1a polyprotein;ORF1ab polyprotein
Protein synonyms
ORF1a polyprotein
Uniprot ID
Mouse ortholog
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 3,885 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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