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Echothiophate
Echothiophate is a small molecule pharmaceutical. Echothiophate was first approved as Phospholine iodide on 1982-01-01. It is known to target acetylcholinesterase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Echothiophate iodide
Tradename
Company
Number
Date
Products
PHOSPHOLINE IODIDEFera PharmaceuticalsN-011963 RX1982-01-01
1 products, RLD, RS
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Labels
FDA
EMA
Brand Name
Status
Last Update
phospholine iodideNew Drug Application2021-11-09
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EB: Parasympathomimetics, antiglaucoma preparations and miotics
— S01EB03: Ecothiopate
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameECHOTHIOPHATE
INN—
Description
Ecothiopate is the phosphorothioate obtained by formal condensation of diethyl phosphate with N,N,N-trimethyl-2-sulfanylethanaminium. An irreversible acetylcholinesterase inhibitor, its iodide salt is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor and a miotic. It is an organic thiophosphate, a member of phosphocholines and a quaternary ammonium ion.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOP(=O)(OCC)SCC[N+](C)(C)C
Identifiers
PDB—
CAS-ID6736-03-4
RxCUI89778
ChEMBL IDCHEMBL1201341
ChEBI ID4753
PubChem CID10548
DrugBankDB01057
UNII ID—
Target
Agency Approved
No data
Alternate
ACHE
ACHE
Organism
Homo sapiens
Gene name
ACHE
Gene synonyms
NCBI Gene ID
43
Protein name
acetylcholinesterase
Protein synonyms
acetylcholinesterase (Yt blood group), apoptosis-related acetylcholinesterase, Yt blood group
Uniprot ID
Q9BXP7
Mouse ortholog
Ache (11423)
acetylcholinesterase (P21836)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 240 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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39 adverse events reported
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