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Econazole
Ecoza (econazole) is a small molecule pharmaceutical. Econazole was first approved as Spectazole on 1982-12-23. It is used to treat cutaneous candidiasis, mycoses, tinea pedis, and tinea versicolor in the USA. It is known to target transient receptor potential cation channel subfamily V member 5 and transient receptor potential cation channel subfamily M member 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Ecoza (generic drugs available since 2002-11-26, discontinued: Spectazole)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Econazole nitrate
Tradename
Company
Number
Date
Products
ECOZAResilia PharmaceuticalsN-205175 RX2013-10-24
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
econazole nitrateANDA2022-04-27
ecozaNew Drug Application2020-10-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cutaneous candidiasis—D002179—
mycoses—D009181B35-B49
tinea pedisEFO_0007512D014008B35.3
tinea versicolorEFO_0007439D014010B36.0
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Econazole Nitrate, Ecoza, Resilia Pharms
100710542031-08-08DP
ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AC: Imidazole and triazole derivatives, topical antifungals
— D01AC03: Econazole
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AF: Imidazole derivatives, gyncological antiinfectives
— G01AF05: Econazole
— G01AF55: Econazole, combinations
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MyopiaD009216H52.1———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameECONAZOLE
INNeconazole
Description
1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group. It is an ether, a member of imidazoles, a dichlorobenzene and a member of monochlorobenzenes.
Classification
Small molecule
Drug classsystemic antifungals (miconazole type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
Identifiers
PDB—
CAS-ID1069-66-5
RxCUI—
ChEMBL IDCHEMBL808
ChEBI ID82873
PubChem CID3198
DrugBankDB01127
UNII ID6Z1Y2V4A7M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TRPV5
TRPV5
TRPM2
TRPM2
Organism
Homo sapiens
Gene name
TRPV5
Gene synonyms
ECAC1
NCBI Gene ID
56302
Protein name
transient receptor potential cation channel subfamily V member 5
Protein synonyms
Calcium transport protein 2, calcium transporter 2, CaT2, ECaC, ECaC1, Epithelial calcium channel 1, Osm-9-like TRP channel 3, OTRPC3
Uniprot ID
Q9NQA5
Mouse ortholog
Trpv5 (194352)
transient receptor potential cation channel subfamily V member 5 (Q2TB50)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,714 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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66 adverse events reported
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