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Efonidipine
Efonidipine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target voltage-dependent L-type calcium channel subunit alpha-1C and voltage-dependent T-type calcium channel subunit alpha-1G.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
1 clinical trials
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Mock data
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemangioendotheliomaD006390————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEFONIDIPINE
INNefonidipine
Description
2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate is a carboxylic ester resulting from the formal condensation of the carboxy group of 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid with the hydroxy group of 2-[benzyl(phenyl)amino]ethanol. It is a C-nitro compound, a carboxylic ester, a tertiary amino compound and a dihydropyridine.
Classification
Small molecule
Drug classphenylpyridine vasodilators; Fc fusion protein; tricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1=C(C(=O)OCCN(Cc2ccccc2)c2ccccc2)C(c2cccc([N+](=O)[O-])c2)C(P2(=O)OCC(C)(C)CO2)=C(C)N1
Identifiers
PDB—
CAS-ID111011-63-3
RxCUI—
ChEMBL IDCHEMBL2074922
ChEBI ID—
PubChem CID119171
DrugBankDB09235
UNII ID40ZTP2T37Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CACNA1C
CACNA1C
CACNA1G
CACNA1G
Organism
Homo sapiens
Gene name
CACNA1C
Gene synonyms
CACH2, CACN2, CACNL1A1, CCHL1A1
NCBI Gene ID
775
Protein name
voltage-dependent L-type calcium channel subunit alpha-1C
Protein synonyms
CACNA1C intronic transcript 2, CACNA1C intronic transcript 2 (non-protein coding), calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit, Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle, calcium channel, voltage-dependent, L type, alpha 1C subunit, DHPR, alpha-1 subunit, voltage-dependent L-type Ca2+ channel alpha 1 subunit, Voltage-gated calcium channel subunit alpha Cav1.2
Uniprot ID
Q13936
Mouse ortholog
Cacna1c (12288)
voltage-dependent L-type calcium channel subunit alpha-1C (Q99242)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 333 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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