Elamipretide
Elamipretide is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mitochondrial diseases | D028361 | EFO_0000591 | — | 2 | 1 | — | 1 | 4 | |
| Mitochondrial myopathies | D017240 | Orphanet_206966 | G71.3 | 1 | 1 | 2 | — | — | 3 |
| Barth syndrome | D056889 | Orphanet_111 | E78.71 | — | 1 | 1 | — | 1 | 2 |
| Cytochrome-c oxidase deficiency | D030401 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart failure | D006333 | EFO_0003144 | I50 | 2 | 3 | — | — | — | 5 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 2 | 2 | — | — | — | 3 |
| Hereditary optic atrophy leber | D029242 | Orphanet_104 | H47.22 | — | 1 | — | — | — | 1 |
| Fuchs' endothelial dystrophy | D005642 | EFO_0003946 | H18.51 | 1 | 1 | — | — | — | 1 |
| Macular edema | D008269 | 1 | 1 | — | — | — | 1 | ||
| St elevation myocardial infarction | D000072657 | — | 1 | — | — | — | 1 | ||
| Reperfusion injury | D015427 | — | 1 | — | — | — | 1 | ||
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ELAMIPRETIDE |
| INN | elamipretide |
| Description | Elamipretide (also known as SS-31, , MTP-131 and Bendavia) is a small mitochondrially-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that appears to reduce the production of toxic reactive oxygen species and stabilize cardiolipin.
|
| Classification | Protein |
| Drug class | peptides |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(O)cc(C)c1C[C@H](NC(=O)[C@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 736992-21-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3833370 |
| ChEBI ID | — |
| PubChem CID | 11764719 |
| DrugBank | DB11981 |
| UNII ID | 87GWG91S09 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 527 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
0 adverse events reported
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