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Viberzi, Truberzi(eluxadoline)
Truberzi, Viberzi (eluxadoline) is a small molecule pharmaceutical. Eluxadoline was first approved as Viberzi on 2015-05-27. It is used to treat irritable bowel syndrome in the USA. It has been approved in Europe to treat diarrhea and irritable bowel syndrome. It is known to target mu-type opioid receptor and delta-type opioid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Viberzi
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Eluxadoline
Tradename
Company
Number
Date
Products
VIBERZIAbbVieN-206940 RX2015-05-27
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
viberziNew Drug Application2020-06-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
irritable bowel syndromeEFO_0000555D043183K58
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Eluxadoline, Viberzi, Abbvie
96755872033-03-14DP
101886322033-03-14DP
110071792033-03-14DP
110902912033-03-14DP
111607922033-03-14DP
112296272033-03-14DP
113115162033-03-14DP
114845272033-03-14U-3475
77413562029-05-27DS, DP
86918602028-07-07DPU-1709
91150912028-07-07DS, DPU-1738
93644892028-07-07U-1709
97891252028-07-07DPU-1709, U-2152
77861582025-03-14DP
83440112025-03-14U-1709
86097092025-03-14DP
87723252025-03-14U-1709
92050762025-03-14U-1709
97005422025-03-14DP
102134152025-03-14DPU-2152
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07D: Antipropulsives
— A07DA: Antipropulsives
— A07DA06: Eluxadoline
HCPCS
No data
Clinical
Clinical Trials
142 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Thrombocytopenic purpura idiopathicD016553EFO_0007160D69.3715126747
ThrombocytopeniaD013921HP_0001873D69.671862331
Hematologic neoplasmsD019337—1—1—2
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Aplastic anemiaD000741HP_0001915D61.9—112—113
Myeloid leukemia acuteD015470C92.0371——8
Hepatitis cD006526B19.2113—26
Chronic hepatitis cD019698EFO_0004220B18.2—12——3
NeoplasmsD009369C801—1——2
Liver diseasesD008107EFO_0001421K70-K77—11——2
Hematopoietic stem cell transplantationD018380——1——1
Primary myelofibrosisD055728D47.4—11——1
Myeloid leukemia chronic-phaseD015466—11——1
Hiv infectionsD015658EFO_0000764B20——1——1
Show 5 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D4637———10
LeukemiaD007938C95—4———4
Wiskott-aldrich syndromeD014923D82.0—2———2
Megakaryoblastic leukemia acuteD007947C94.211———2
Monocytic leukemia acuteD00794811———2
Myelomonocytic leukemia acuteD015479C92.511———2
Myeloid leukemiaD007951C9211———2
Basophilic leukemia acuteD015471C94.811———2
Erythroblastic leukemia acuteD004915EFO_1001257C94.011———2
Eosinophilic leukemia acuteD01547211———2
Show 14 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Liver cirrhosisD008103EFO_0001422K74.01————1
SarcomaD0125091————1
OsteosarcomaD0125161————1
Connective and soft tissue neoplasmsD0182041————1
Acute radiation syndromeD0545081————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameELUXADOLINE
INNeluxadoline
Description
Eluxadoline is an amino acid amide obtained by the formal condensation of the carboxy group of 4-carbamoyl-2,6-dimethyl-L-phenylalanine with the secondary amino group of 2-methoxy-5-({[(1S)-1-(4-phenylimidazol-2-yl)ethyl]amino}methyl)benzoic acid. It has mixed opioid receptor activity and is used for treatment of irritable bowel syndrome with diarrhoea. It has a role as a mu-opioid receptor agonist, a delta-opioid receptor antagonist, a kappa-opioid receptor agonist and a gastrointestinal drug. It is a member of imidazoles, a methoxybenzoic acid, a member of benzamides, a L-phenylalanine derivative and an amino acid amide.
Classification
Small molecule
Drug classanalgesics (mixed opiate receptor agonists/antagonists)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(CN(C(=O)[C@@H](N)Cc2c(C)cc(C(N)=O)cc2C)[C@@H](C)c2ncc(-c3ccccc3)[nH]2)cc1C(=O)O
Identifiers
PDB—
CAS-ID864821-90-9
RxCUI1653781
ChEMBL IDCHEMBL2159122
ChEBI ID85980
PubChem CID11250029
DrugBankDB09272
UNII ID45TPJ4MBQ1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
OPRM1
OPRM1
OPRD1
OPRD1
Organism
Homo sapiens
Gene name
OPRM1
Gene synonyms
MOR1
NCBI Gene ID
4988
Protein name
mu-type opioid receptor
Protein synonyms
hMOP, MOP, Mu opiate receptor, Mu opioid receptor, mu opioid receptor hMOR-1a
Uniprot ID
Q9UN57
Mouse ortholog
Oprm1 (18390)
mu-type opioid receptor (P42866)
Variants
Clinical Variant
No data
Financial
Viberzi - Allergan
$
€
£
₣
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Viberzi - Ironwood Pharmaceuticals
$
€
£
₣
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Viberzi - Warner Chilcott
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 333 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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17,849 adverse events reported
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