Ensifentrine
Ensifentrine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | 8 | 3 | — | — | 12 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | — | 1 | |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 1 | — | — | — | 1 |
| Sars-cov-2 | D000086402 | — | 1 | — | — | — | 1 | ||
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ENSIFENTRINE |
| INN | ensifentrine |
| Description | Ensifentrine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A. |
| Classification | Small molecule |
| Drug class | phosphodiesterase inhibitor |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc2c(cc1OC)-c1c/c(=N\c3c(C)cc(C)cc3C)n(CCNC(N)=O)c(=O)n1CC2 |
Identifiers
| PDB | — |
| CAS-ID | 1884461-72-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4594287 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 3E3D8T1GIX (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE4A
PDE4A
PDE3A
PDE3A
Organism
Homo sapiens
Gene name
PDE4A
Gene synonyms
DPDE2
NCBI Gene ID
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Protein synonyms
DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, phosphodiesterase isozyme 4
Uniprot ID
Mouse ortholog
Pde4a (18577)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (O89084)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 55 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2 adverse events reported
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