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Comtan, Comtess(entacapone)
Comtan, Comtess, Corbilta, Levodopa/Carbidopa/Entacapone, Stalevo (entacapone) is a small molecule pharmaceutical. Entacapone was first approved as Comtess on 1998-09-16. It is used to treat parkinson disease in the USA. It has been approved in Europe to treat parkinson disease. The pharmaceutical is active against catechol O-methyltransferase. In addition, it is known to target alpha-ketoglutarate-dependent dioxygenase FTO.
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SARS-CoV-2 Interaction
Novartis Pharmaceuticals
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
Comtan (generic drugs available since 2012-05-10)
Combinations
Stalevo (generic drugs available since 2012-05-10)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carbidopa
+
Entacapone
+
Levodopa
Tradename
Company
Number
Date
Products
STALEVO 75Orion PharmaN-021485 RX2008-08-29
1 products, RLD
STALEVO 125Orion PharmaN-021485 RX2008-08-29
1 products, RLD
STALEVO 200Orion PharmaN-021485 RX2007-08-02
1 products, RLD, RS
STALEVO 50Orion PharmaN-021485 RX2003-06-11
1 products, RLD, RS
STALEVO 100Orion PharmaN-021485 RX2003-06-11
1 products, RLD
STALEVO 150Orion PharmaN-021485 RX2003-06-11
1 products, RLD
Entacapone
Tradename
Company
Number
Date
Products
COMTANOrion PharmaN-020796 RX1999-10-19
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
comtanNew Drug Application2020-05-01
entacaponeANDA2023-06-21
stalevoNew Drug Application2020-05-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BX: Other dopaminergic agents in atc
— N04BX02: Entacapone
HCPCS
No data
Clinical
Clinical Trials
45 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G2099311131
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F14111——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple system atrophyD01957821———2
ObesityD009765EFO_0001073E66.911———1
Autonomic nervous system diseasesD001342EFO_0009532G9011———1
TachycardiaD013610HP_0001649R00.011———1
Orthostatic intoleranceD05497111———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—6————6
Pure autonomic failureD0549701————1
DementiaD003704F031————1
PharmacokineticsD0105991————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sleep wake disordersD012893G47————11
SchizophreniaD012559EFO_0000692F20————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameENTACAPONE
INNentacapone
Description
Entacapone is a monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group. It has a role as an EC 2.1.1.6 (catechol O-methyltransferase) inhibitor, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent. It is a monocarboxylic acid amide, a nitrile, a member of catechols and a member of 2-nitrophenols.
Classification
Small molecule
Drug classcatechol-O-methyltransferase (COMT) inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)C(=O)/C(C#N)=C/c1cc(O)c(O)c([N+](=O)[O-])c1
Identifiers
PDB6AK4
CAS-ID130929-57-6
RxCUI60307
ChEMBL IDCHEMBL953
ChEBI ID4798
PubChem CID5281081
DrugBankDB00494
UNII ID4975G9NM6T (ChemIDplus, GSRS)
Target
Agency Approved
COMT
COMT
Organism
Homo sapiens
Gene name
COMT
Gene synonyms
NCBI Gene ID
1312
Protein name
catechol O-methyltransferase
Protein synonyms
epididymis secretory sperm binding protein Li 98n, testicular tissue protein Li 42
Uniprot ID
Q9BWC7
Mouse ortholog
Comt (12846)
catechol O-methyltransferase (Q91XH4)
Alternate
FTO
FTO
Organism
Homo sapiens
Gene name
FTO
Gene synonyms
KIAA1752
NCBI Gene ID
79068
Protein name
alpha-ketoglutarate-dependent dioxygenase FTO
Protein synonyms
AlkB homolog 9, fat mass and obesity associated, Fat mass and obesity-associated protein, intragenic FTO exon 9 containing transcript, m6A(m)-demethylase FTO, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, mRNA N(6)-methyladenosine demethylase FTO, tRNA N1-methyl adenine demethylase FTO, U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO, U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
Uniprot ID
Q9C0B1
Mouse ortholog
Fto (26383)
alpha-ketoglutarate-dependent dioxygenase FTO (Q9QZ13)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,337 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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26,856 adverse events reported
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