Entospletinib
Entospletinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase SYK.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| B-cell chronic lymphocytic leukemia | D015451 | C91.1 | 1 | 4 | — | — | — | 4 | |
| Non-hodgkin lymphoma | D008228 | C85.9 | 1 | 3 | — | — | — | 3 | |
| Mantle-cell lymphoma | D020522 | C83.1 | 1 | 3 | — | — | — | 3 | |
| Large b-cell lymphoma diffuse | D016403 | C83.3 | — | 2 | — | — | — | 2 | |
| Follicular lymphoma | D008224 | C82 | 1 | 2 | — | — | — | 2 | |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 1 | 1 | — | — | — | 1 | |
| Anemia | D000740 | EFO_0004272 | D64.9 | 1 | 1 | — | — | — | 1 |
| Waldenstrom macroglobulinemia | D008258 | C88.0 | 1 | 1 | — | — | — | 1 | |
| Hairy cell leukemia | D007943 | C91.4 | 1 | 1 | — | — | — | 1 | |
| Reactive arthritis | D016918 | EFO_0007460 | M02.3 | 1 | 1 | — | — | — | 1 |
Show 1 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | ENTOSPLETINIB |
| INN | entospletinib |
| Description | Entospletinib is an experimental drug for the treatment of various types of cancer under development by Gilead Sciences. It is an inhibitor of spleen tyrosine kinase (Syk). It has entered clinical trials for acute myeloid leukaemia (AML), chronic lymphocytic leukemia (CLL), diffuse large B cell lymphoma (DLBCL), graft-versus-host disease (GvHD), hematological malignancies, mantle cell lymphoma (MCL), and non-Hodgkin lymphoma (NHL).
|
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | c1cn2cc(-c3ccc4cn[nH]c4c3)nc(Nc3ccc(N4CCOCC4)cc3)c2n1 |
Identifiers
| PDB | — |
| CAS-ID | 1229208-44-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3265032 |
| ChEBI ID | — |
| PubChem CID | 59473233 |
| DrugBank | DB12121 |
| UNII ID | 6I3O3W6O3B (ChemIDplus, GSRS) |
Target
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 352 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
10 adverse events reported
View more details
Premium feature
Learn more about premium features at pharmakb.com
Learn more