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Epalrestat
Epalrestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cytochrome P450 4A11.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hereditary congenital and neonatal diseases and abnormalitiesD009358——1——1
Hemophilia bD002836D67——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Triple negative breast neoplasmsD064726—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEPALRESTAT
INNepalrestat
Description
Epalrestat is a monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor. It is a member of thiazolidines and a monocarboxylic acid.
Classification
Small molecule
Drug classenzyme inhibitors: aldose-reductase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1
Identifiers
PDB—
CAS-ID82159-09-9
RxCUI—
ChEMBL IDCHEMBL56337
ChEBI ID31539
PubChem CID1549120
DrugBankDB15293
UNII ID424DV0807X (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP4A11
CYP4A11
Organism
Homo sapiens
Gene name
CYP4A11
Gene synonyms
CYP4A2
NCBI Gene ID
1579
Protein name
cytochrome P450 4A11
Protein synonyms
20-HETE synthase, 20-hydroxyeicosatetraenoic acid synthase, alkane-1 monooxygenase, CYP4AII, CYPIVA11, Cytochrome P-450HK-omega, cytochrome P450, family 4, subfamily A, polypeptide 11, cytochrome P450, subfamily IVA, polypeptide 11, Cytochrome P450HL-omega, Fatty acid omega-hydroxylase, Lauric acid omega-hydroxylase, Long-chain fatty acid omega-monooxygenase, P450HL-omega
Uniprot ID
Q8IWY5
Mouse ortholog
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Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 638 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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47 adverse events reported
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