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Ergonovine
Ergonovine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 1E and 5-hydroxytryptamine receptor 2A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
postpartum hemorrhage—D006473O72
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02A: Uterotonics
— G02AB: Ergot alkaloid oxytocics
— G02AB03: Ergometrine
HCPCS
Code
Description
J1330
Injection, ergonovine maleate, up to 0.2 mg
J2210
Injection, methylergonovine maleate, up to 0.2 mg
Clinical
Clinical Trials
9 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemorrhageD006470MP_0001914R58——21—3
Postpartum hemorrhageD006473O72———123
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Surgical blood lossD016063————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameERGONOVINE
INNergometrine
Description
Ergometrine is a monocarboxylic acid amide that is lysergamide in which one of the hydrogens attached to the amide nitrogen is substituted by a 1-hydroxypropan-2-yl group (S-configuration). An ergot alkaloid that has a particularly powerful action on the uterus, its maleate (and formerly tartrate) salt is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by maintaining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced. It has a role as an oxytocic, a diagnostic agent, a toxin and a fungal metabolite. It is an ergot alkaloid, a monocarboxylic acid amide, a primary alcohol, a tertiary amino compound, an organic heterotetracyclic compound and a secondary amino compound. It derives from a hydride of an ergoline.
Classification
Small molecule
Drug classvinca alkaloids
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1
Identifiers
PDB—
CAS-ID60-79-7
RxCUI4021
ChEMBL IDCHEMBL119443
ChEBI ID4822
PubChem CID443884
DrugBankDB01253
UNII IDWH41D8433D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR1E
HTR1E
HTR2A
HTR2A
Organism
Homo sapiens
Gene name
HTR1E
Gene synonyms
NCBI Gene ID
3354
Protein name
5-hydroxytryptamine receptor 1E
Protein synonyms
5-HT-1E, 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled, S31, Serotonin receptor 1E
Uniprot ID
Q9P1Y1
Mouse ortholog
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—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,737 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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258 adverse events reported
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