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Ergotamine
Cafergot, Ergostat, Wigraine, Wigrettes (ergotamine) is a small molecule pharmaceutical. Ergotamine was first approved as Cafergot on 1982-01-01. It is used to treat cluster headache and migraine disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 1D. In addition, it is known to target 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 6, and 5-hydroxytryptamine receptor 7.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Caffeine
+
Ergotamine tartrate
Tradename
Company
Number
Date
Products
CAFERGOTNovartisN-006620 DISCN1982-01-01
1 products
CAFERGOTNovartisN-009000 DISCN1982-01-01
1 products, RLD
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Ergotamine tartrate
Tradename
Company
Number
Date
Products
MEDIHALER ERGOTAMINE3MN-012102 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
cafergotANDA2019-12-16
ergomar ANDA2020-09-04
migergotANDA2019-08-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cluster headacheHP_0012199D003027G44.00
migraine disordersEFO_0003821D008881G43
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CA: Ergot alkaloids, antimigraine
— N02CA02: Ergotamine
— N02CA52: Ergotamine, combinations excl. psycholeptics
— N02CA72: Ergotamine, combinations with psycholeptics
HCPCS
Code
Description
J1110
Injection, dihydroergotamine mesylate, per 1 mg
Clinical
Clinical Trials
7 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Essential hypertensionD000075222I10——11—2
Healthy volunteers/patients————1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.1——1——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Kidney diseasesD007674EFO_0003086N081————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10————11
Type 2 diabetes mellitusD003924EFO_0001360E11————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameERGOTAMINE
INNergotamine
Description
Ergotamine is a peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. It has a role as a non-narcotic analgesic, a vasoconstrictor agent, a serotonergic agonist, an alpha-adrenergic agonist, a mycotoxin and an oxytocic. It is a conjugate base of an ergotamine(1+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21
Identifiers
PDB4IB4
CAS-ID113-15-5
RxCUI4025
ChEMBL IDCHEMBL442
ChEBI ID64318
PubChem CID8223
DrugBankDB00696
UNII IDPR834Q503T (ChemIDplus, GSRS)
Target
Agency Approved
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR1D
Gene synonyms
HTR1DA, HTRL
NCBI Gene ID
3352
Protein name
5-hydroxytryptamine receptor 1D
Protein synonyms
5-HT-1D, 5-HT-1D-alpha, 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled, Serotonin 1D alpha receptor, Serotonin receptor 1D
Uniprot ID
P28221
Mouse ortholog
Htr1d (15552)
5-hydroxytryptamine receptor 1D (Q8BUW7)
Alternate
HTR1F
HTR1F
HTR2B
HTR2B
HTR2A
HTR2A
HTR1E
HTR1E
HTR5A
HTR5A
HTR2C
HTR2C
HTR6
HTR6
HTR7
HTR7
Organism
Homo sapiens
Gene name
HTR1F
Gene synonyms
HTR1EL
NCBI Gene ID
3355
Protein name
5-hydroxytryptamine receptor 1F
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled, Serotonin receptor 1F
Uniprot ID
P30939
Mouse ortholog
Htr1f (15557)
5-hydroxytryptamine receptor 1F (Q02284)
Variants
Clinical Variant
No data
Financial
Migergot - Horizon Therapeutics Public
$
€
£
₣
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,789 documents
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Safety
Black-box Warning
Black-box warning for: Cafergot, Ergomar , Migergot
Adverse Events
Top Adverse Reactions
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480 adverse events reported
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