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Ergotamine tartrate
Cafergot, Ergostat, Wigraine, Wigrettes (ergotamine tartrate) is a small molecule pharmaceutical. Ergotamine tartrate was first approved as Cafergot on 1982-01-01. It is used to treat cluster headache, migraine disorders, and postpartum hemorrhage in the USA. It is known to target 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1E, and 5-hydroxytryptamine receptor 1D.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
urogenital diseasesD000091642
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Caffeine
+
Ergotamine tartrate
Tradename
Company
Number
Date
Products
CAFERGOTNovartisN-006620 DISCN1982-01-01
1 products
CAFERGOTNovartisN-009000 DISCN1982-01-01
1 products, RLD
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Ergotamine tartrate
Tradename
Company
Number
Date
Products
MEDIHALER ERGOTAMINE3MN-012102 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
cafergotANDA2019-12-16
ergomar ANDA2020-09-04
migergotANDA2019-08-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
cluster headacheHP_0012199D003027G44.00
migraine disordersEFO_0003821D008881G43
postpartum hemorrhage—D006473O72
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CA: Ergot alkaloids, antimigraine
— N02CA02: Ergotamine
— N02CA52: Ergotamine, combinations excl. psycholeptics
— N02CA72: Ergotamine, combinations with psycholeptics
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pure autonomic failureD0549701————1
Orthostatic hypotensionD007024I95.11————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameERGOTAMINE TARTRATE
INNergotamine
Description
Ergotamine is a peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. It has a role as a non-narcotic analgesic, a vasoconstrictor agent, a serotonergic agonist, an alpha-adrenergic agonist, a mycotoxin and an oxytocic. It is a conjugate base of an ergotamine(1+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21.CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21.O=C(O)C(O)C(O)C(=O)O
Identifiers
PDB—
CAS-ID113-15-5
RxCUI4025
ChEMBL IDCHEMBL2448612
ChEBI ID—
PubChem CID8223
DrugBankDB00696
UNII IDPR834Q503T (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR6
HTR6
HTR2C
HTR2C
HTR5A
HTR5A
HTR1F
HTR1F
HTR2B
HTR2B
HTR2A
HTR2A
HTR1E
HTR1E
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
3362
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Q5TGZ1
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Variants
Clinical Variant
No data
Financial
Migergot - Horizon Therapeutics Public
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,789 documents
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Safety
Black-box Warning
Black-box warning for: Cafergot, Ergomar , Migergot
Adverse Events
Top Adverse Reactions
Mock data
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31,520 adverse events reported
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