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Invanz(ertapenem)
Invanz (ertapenem) is a small molecule pharmaceutical. Ertapenem was first approved as Invanz on 2001-11-21. It is used to treat abdominal abscess, bacterial infections, bacteroides infections, escherichia coli infections, and haemophilus infections amongst others in the USA. It has been approved in Europe to treat bacterial infections, bacterial pneumonia, community-acquired infections, gram-negative bacterial infections, and staphylococcal infections amongst others.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Invanz (generic drugs available since 2018-04-16)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ertapenem sodium
Tradename
Company
Number
Date
Products
INVANZMerck Sharp & DohmeN-021337 RX2001-11-21
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ertapenemNew Drug Application2022-11-07
invanzNew Drug Application2020-12-22
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
abdominal abscessEFO_1001753D018784—
bacterial infections—D001424A49
bacteroides infectionsEFO_1000832D001442—
escherichia coli infectionsEFO_1001318D004927B96.20
haemophilus infectionsEFO_1001127D006192—
intraabdominal infections—D059413—
klebsiella infectionsEFO_1001353D007710—
pelvic infection—D034161—
pneumoniaEFO_0003106D011014J18
pyelonephritisEFO_1001141D011704N10-N16
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01D: Other beta-lactam antibacterials in atc
— J01DH: Carbapenems
— J01DH03: Ertapenem
HCPCS
Code
Description
J1335
Injection, ertapenem sodium, 500 mg
Clinical
Clinical Trials
69 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary tract infectionsD014552EFO_0003103N39.0—3112115
Intraabdominal infectionsD059413—152—8
InfectionsD007239EFO_0000544—232—7
Healthy volunteers/patients—1——2—3
SepsisD018805A41.9——11—2
Escherichia coli infectionsD004927EFO_1001318B96.20—111—2
Chronic kidney failureD007676EFO_0003884N18.6—1—1—2
Pyogenic liver abscessD046290EFO_1001836———1—1
Urinary bladder neoplasmsD001749C67———1—1
Liver cirrhosisD008103EFO_0001422K74.0———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial infectionsD001424A491—1—13
BacteremiaD016470EFO_0003033R78.81—11—13
PneumoniaD011014EFO_0003106J18—12——3
Surgical wound infectionD013530—12——2
PyelonephritisD011704EFO_1001141N10-N16—11——2
Diabetic footD017719EFO_1001459——2——2
GonorrheaD006069DOID_7551A54——1——1
Kidney transplantationD016030—11——1
Klebsiella infectionsD007710EFO_1001353—11——1
OsteomyelitisD010019EFO_0003102M86——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Soft tissue infectionsD018461—1———1
Bacterial pneumoniaD018410EFO_1001272J15.9—1———1
Pelvic infectionD034161—1———1
EndocarditisD004696EFO_0000465I33—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EndometritisD004716EFO_10013121————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AppendicitisD001064EFO_0007149K37————22
Surgical amputationD000671————11
Hidradenitis suppurativaD017497L73.2————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameERTAPENEM
INNertapenem
Description
Ertapenem is meropenem in which the one of the two methyl groups attached to the amide nitrogen is replaced by hydrogen while the other is replaced by a 3-carboxyphenyl group. The sodium salt is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract. It has a role as an antibacterial drug. It is a carbapenemcarboxylic acid and a pyrrolidinecarboxamide. It is a conjugate acid of an ertapenem(1-).
Classification
Small molecule
Drug classantibacterial antibiotics, carbapenem derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C[C@@H](O)[C@H]1C(=O)N2C(C(=O)O)=C(S[C@@H]3CN[C@H](C(=O)Nc4cccc(C(=O)O)c4)C3)[C@H](C)[C@H]12
Identifiers
PDB—
CAS-ID153832-46-3
RxCUI325642
ChEMBL IDCHEMBL1359
ChEBI ID404903
PubChem CID150610
DrugBankDB00303
UNII IDG32F6EID2H (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Invanz - Merck Sharp & Dohme
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,279 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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47,554 adverse events reported
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