Erythromycin lactobionate

Benzamycin, Bristamycin, E.e.s, Eryc, Erygel, Erypar, Eryped, Erythrocin, Eryzole, Ethril, Ilosone, Ilotycin, Pediazole, Pfizer, Wyamycin (erythromycin lactobionate) is a small molecule pharmaceutical. Erythromycin lactobionate was first approved as Ilotycin on 1982-01-01. It is used to treat acne vulgaris, bacterial eye infections, bacterial infections, campylobacter infections, and chancroid amongst others in the USA. It is known to target motilin receptor.

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Therapeutic Areas

Therapeutic Area	MeSH
infections	D007239
digestive system diseases	D004066
respiratory tract diseases	D012140
eye diseases	D005128
urogenital diseases	D000091642
skin and connective tissue diseases	D017437

Trade Name

FDA

EMA

E.e.s, Eryc, Erygel, Eryped, Erythrocin (generic drugs available since 1982-01-01, discontinued: A/t/s, Akne-mycin, Bristamycin, C-solve, E-base, E-glades, E-mycin, E-solve, E.e.s., Emgel, Eryc sprinkles, Erycette, Eryderm, Erymax, Erypar, Erythro-statin, Ethril, Ilosone, Ilotycin, Pce, Pediamycin, Pfizer, R-p mycin, Robimycin, Sansac, Staticin, T-stat, Wyamycin)

Combinations

Benzamycin (generic drugs available since 1982-01-01, discontinued: Aktipak, Eryzole, Ilosone sulfa, Pediazole)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Benzoyl peroxide

Erythromycin

Tradename	Company	Number	Date	Products
BENZAMYCIN	Bausch Health Companies	N-050557 RX	1984-10-26	1 products, RLD, RS

Show 1 discontinued

Erythromycin

Tradename	Company	Number	Date	Products
ERYC	Dr Reddys Laboratories	N-050536 RX	1982-01-01	1 products, RLD, RS
ERYGEL	Mylan	N-050617 RX	1987-10-21	1 products, RLD, RS

Show 8 discontinued

Erythromycin estolate

Tradename	Company	Number	Date	Products
ILOSONE	Eli Lilly	N-050010 DISCN	1982-01-01	2 products

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Erythromycin estolate

Sulfisoxazole acetyl

Tradename	Company	Number	Date	Products
ILOSONE SULFA	Eli Lilly	N-050599 DISCN	1989-09-29	1 products

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Erythromycin ethylsuccinate

Tradename	Company	Number	Date	Products
ERYPED	Azurity	N-050207 RX	1987-03-30	1 products, RLD
E.E.S.	Azurity	N-050207 RX	1982-01-01	1 products, RLD
ERYPED	Azurity	N-050207 RX	1982-01-01	1 products, RLD, RS

Show 2 discontinued

Erythromycin ethylsuccinate

Sulfisoxazole acetyl

Tradename	Company	Number	Date	Products
PEDIAZOLE	Ross Laboratories	N-050529 DISCN	1982-01-01	1 products

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Erythromycin gluceptate

Tradename	Company	Number	Date	Products
ILOTYCIN GLUCEPTATE	Dista Products	N-050370 DISCN	1982-01-01	3 products

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Erythromycin lactobionate

Tradename	Company	Number	Date	Products
ERYTHROCIN	Hospira	N-050609 RX	1986-09-24	1 products, RLD, RS

Show 2 discontinued

Labels

FDA

EMA

Brand Name	Status	Last Update
benzamycin	New Drug Application	2020-11-30
ery-tab	ANDA	2022-08-23
erygel	New Drug Application	2018-06-21
erythrocin lactobionate	New Drug Application	2022-12-28
erythromycin	ANDA	2023-06-07
erythromycin lactobionate	ANDA	2023-03-09

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
acne vulgaris	EFO_0003894	D000152	L70
bacterial eye infections	—	D015818	—
bacterial infections	—	D001424	A49
campylobacter infections	EFO_0007190	D002169	—
chancroid	—	D002602	A57
chlamydia infections	EFO_0007205	D002690	A74.9
erythrasma	—	D004894	L08.1
gastroenteritis	EFO_1001463	D005759	K52.9
gonorrhea	DOID_7551	D006069	A54
legionnaires' disease	EFO_0007343	D007877	A48.1

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Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

D: Dermatologicals

— D10: Anti-acne preparations

— D10A: Anti-acne preparations for topical use

— D10AF: Antiinfectives for treatment of acne

— D10AF02: Erythromycin

— D10AF52: Erythromycin, combinations

J: Antiinfectives for systemic use

— J01: Antibacterials for systemic use

— J01F: Macrolides, lincosamides and streptogramins

— J01FA: Macrolides

— J01FA01: Erythromycin

S: Sensory organ drugs

— S01: Ophthalmologicals

— S01A: Antiinfective ophthalmologics

— S01AA: Antibiotics, ophthalmologic

— S01AA17: Erythromycin

HCPCS

Code	Description
J1364	Injection, erythromycin lactobionate, per 500 mg

Clinical

Clinical Trials

34 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pulmonary arterial hypertension	D000081029			1	1	2	2	2	8
Pulmonary hypertension	D006976	EFO_0001361	I27.20	1	1	1	3	1	7
Heart failure	D006333	EFO_0003144	I50	—	—	2	1	—	3
Cardiovascular diseases	D002318	EFO_0000319	I98	—	—	—	1	1	2
Pulmonary embolism	D011655	EFO_0003827	I26	—	—	—	1	—	1
Acute kidney injury	D058186	HP_0001919	N17	—	—	—	1	—	1
Type 2 diabetes mellitus	D003924	EFO_0001360	E11	—	—	—	1	—	1

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Heart diseases	D006331	EFO_0003777	I51.9	—	—	1	—	—	1

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Reperfusion injury	D015427			1	1	—	—	—	2
Covid-19	D000086382		U07.1	—	1	—	—	—	1
Subarachnoid hemorrhage	D013345	EFO_0000713	I60	—	1	—	—	—	1
Right ventricular dysfunction	D018497			—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Migraine disorders	D008881	EFO_0003821	G43	1	—	—	—	1	2
Headache	D006261	HP_0002315	R51	1	—	—	—	1	2
Traumatic brain injuries	D000070642		S06	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Respiratory distress syndrome	D012128	EFO_1000637	J80	—	—	—	—	1	1
Vasodilation	D014664			—	—	—	—	1	1

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	ERYTHROMYCIN LACTOBIONATE
INN	erythromycin
Description	Erythromycin A is an erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. It is an erythromycin and a cyclic ketone. It is functionally related to an erythronolide A. It is a conjugate base of an erythromycin A(1+).
Classification	Small molecule
Drug class	antibiotics (Streptomyces strain)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=C(O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO

Identifiers

PDB	—
CAS-ID	114-07-8
RxCUI	4053
ChEMBL ID	CHEMBL1200506
ChEBI ID	—
PubChem CID	12560
DrugBank	DB00199
UNII ID	63937KV33D (ChemIDplus, GSRS)

Target

Agency Approved

No data

Alternate

MLNR

Organism

Homo sapiens

Gene name

MLNR

Gene synonyms

GPR38, MTLR, MTLR1

NCBI Gene ID

2862

Protein name

motilin receptor

Protein synonyms

G protein-coupled receptor 38, G-protein coupled receptor 38

Uniprot ID

O43193

Mouse ortholog

—

Variants

Clinical Variant

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Financial

No data

Trends

PubMed Central

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Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

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15,029 adverse events reported

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