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Estrogens, esterified
Amnestrogen, Duavee, Estratab, Evex, Femogen, Menrium, Milprem, Pmb, Premarin, Premphase, Prempro (estrogens, esterified) is a small molecule pharmaceutical. Estrogens, esterified was first approved as Menrium 5-2 on 1982-01-01.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Premarin (generic drugs available since 1982-01-01, discontinued: Amnestrogen, Estratab, Evex, Femogen)
Combinations
Duavee, Premphase, Prempro (discontinued: Menrium, Milprem, Pmb, Premphase (premarin;cycrin ), Prempro (premarin;cycrin))
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bazedoxifene acetate
+
Estrogens
+
conjugated
Tradename
Company
Number
Date
Products
DUAVEEWYETH PHARMSN-022247 RX2013-10-03
1 products, RLD, RS
Chlordiazepoxide
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Estrogens
+
esterified
Tradename
Company
Number
Date
Products
MENRIUM 5-2RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 5-4RocheN-014740 DISCN1982-01-01
1 products
MENRIUM 10-4RocheN-014740 DISCN1982-01-01
1 products
Hide discontinued
Estrogens
+
conjugated
Tradename
Company
Number
Date
Products
PREMARINWYETH PHARMSN-004782 RX1982-01-01
5 products, RLD, RS
PREMARINWYETH PHARMSN-010402 RX1982-01-01
1 products, RLD, RS
PREMARINWYETH PHARMSN-020216 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Estrogens
+
conjugated
+
Medroxyprogesterone acetate
Tradename
Company
Number
Date
Products
PREMPROWYETH PHARMSN-020527 RX1995-11-17
4 products, RLD, RS
PREMPHASE 14/14WYETH PHARMSN-020527 RX1995-11-17
1 products, RLD, RS
Show 2 discontinued
Estrogens
+
conjugated
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Meprobamate
Tradename
Company
Number
Date
Products
MILPREM-400Medpointe Pharm HlcN-011045 DISCN1982-01-01
1 products
MILPREM-200Medpointe Pharm HlcN-011045 DISCN1982-01-01
1 products
PMB 400WyethN-010971 DISCN1982-01-01
1 products
PMB 200WyethN-010971 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
duaveeNew Drug Application2022-12-20
esterified estrogens and methyltestosteroneunapproved drug other2023-04-21
esterified estrogens and methyltestosteroneunapproved drug other2023-04-21
menestANDA2020-11-20
premarinNew Drug Application2022-11-28
premphase premproNew Drug Application2019-12-04
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Bazedoxifene Acetate / Estrogens, Conjugated, Duavee, Wyeth Pharms
76830512027-03-10DS, DPU-594, U-904
64795352024-05-06DPU-594, U-904
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03A: Hormonal contraceptives for systemic use
— G03AA: Progestogens and estrogen systemic contraceptives, fixed combinations
— G03AA14: Nomegestrol and estradiol
— G03AA17: Medroxyprogesterone and estradiol
— G03AB: Progestogens and estrogens systemic contraceptives, sequential preparations
— G03AB08: Dienogest and estradiol
— G03C: Estrogens, sex hormones and modulators of the genital system
— G03CA: Natural and semisynthetic estrogens, plain
— G03CA03: Estradiol
— G03CA53: Estradiol, combinations
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01C: Hypothalamic hormones
— H01CC: Anti-gonadotropin-releasing hormones
— H01CC54: Relugolix, estradiol and norethisterone
HCPCS
No data
Clinical
Clinical Trials
50 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C6111308——42
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50—3———3
LymphomaD008223C85.912———2
AdenocarcinomaD000230—1———1
Castration-resistant prostatic neoplasmsD064129—1———1
ThromboembolismD013923HP_0001907—1———1
LeukemiaD007938C9511———1
NeoplasmsD009369C8011———1
SarcomaD01250911———1
Kidney neoplasmsD007680EFO_0003865C64—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameESTROGENS, ESTERIFIED
INN—
Description
17beta-estradiol is the 17beta-isomer of estradiol. It has a role as an estrogen, a human metabolite, an EC 1.2.3.1 (aldehyde oxidase) inhibitor, a Daphnia magna metabolite, a mouse metabolite and a geroprotector. It is a 17beta-hydroxy steroid and an estradiol.
Classification
Small molecule
Drug classestrogens; steroids (androgens, anabolics)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID141290-02-0
RxCUI—
ChEMBL IDCHEMBL1201468
ChEBI ID—
PubChem CID—
DrugBankDB09381
UNII ID—
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Premarin - Pfizer
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,742 documents
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Safety
Black-box Warning
Black-box warning for: Duavee, Esterified estrogens and methyltestosterone, Esterified estrogens and methyltestosterone, Menest, Premarin, Premphase prempro
Adverse Events
Top Adverse Reactions
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555 adverse events reported
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