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Etavopivat
Etavopivat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target pyruvate kinase PKLR.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sickle cell anemiaD000755EFO_0000697D57121——3
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ThalassemiaD013789EFO_1001996D56—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameETAVOPIVAT
INNetavopivat
Description
Etavopivat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target pyruvate kinase PKLR.
Classification
Small molecule
Drug classpyruvate kinase activators
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C([C@H](CO)c1ccccc1)N1CC2=C(C1)CN(S(=O)(=O)c1cnc3c(c1)OCCO3)C2
Identifiers
PDB—
CAS-ID2245053-57-8
RxCUI—
ChEMBL IDCHEMBL4650332
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDV4E0A9M44Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PKLR
PKLR
Organism
Homo sapiens
Gene name
PKLR
Gene synonyms
PK1, PKL
NCBI Gene ID
5313
Protein name
pyruvate kinase PKLR
Protein synonyms
Pyruvate kinase 1, pyruvate kinase isozyme R/L, Pyruvate kinase isozymes L/R, pyruvate kinase isozymes R/L, pyruvate kinase type L, pyruvate kinase, liver and blood cell, pyruvate kinase, liver and RBC, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase
Uniprot ID
P30613
Mouse ortholog
Pklr (18770)
pyruvate kinase PKLR (P53657)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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