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Ethopropazine
Parsidol (ethopropazine) is a small molecule pharmaceutical. Ethopropazine was first approved as Parsidol on 1982-01-01. It is known to target muscarinic acetylcholine receptor M2 and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ethopropazine hydrochloride
Tradename
Company
Number
Date
Products
PARSIDOLPfizerN-009078 DISCN1982-01-01
3 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04A: Anticholinergic agents
— N04AA: Tertiary amines, anticholinergic
— N04AA05: Profenamine
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9—2———2
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Kallmann syndromeD017436Orphanet_478E23.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameETHOPROPAZINE
INNprofenamine
Description
Profenamine is a member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease. It has a role as a muscarinic antagonist, an antiparkinson drug, a histamine antagonist, an adrenergic antagonist and an antidyskinesia agent. It is a member of phenothiazines and a tertiary amino compound.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)C(C)CN1c2ccccc2Sc2ccccc21
Identifiers
PDB—
CAS-ID522-00-9
RxCUI4134
ChEMBL IDCHEMBL1206
ChEBI ID313639
PubChem CID3290
DrugBankDB00392
UNII ID7WI4P02YN1 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CHRM2
CHRM2
CHRM1
CHRM1
Organism
Homo sapiens
Gene name
CHRM2
Gene synonyms
NCBI Gene ID
1129
Protein name
muscarinic acetylcholine receptor M2
Protein synonyms
7TM receptor, acetylcholine receptor, muscarinic 2, muscarinic M2 receptor
Uniprot ID
Q9P1X9
Mouse ortholog
Chrm2 (243764)
muscarinic acetylcholine receptor M2 (Q9ERZ4)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 441 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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642 adverse events reported
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