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Etomidate
Amidate (etomidate) is a small molecule pharmaceutical. Etomidate was first approved as Amidate on 1982-09-07. It is used to treat brain ischemia, closed head injuries, pain, and status epilepticus in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Amidate (generic drugs available since 1996-11-04)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Etomidate
Tradename
Company
Number
Date
Products
AMIDATEHospiraN-018227 RX1982-09-07
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
amidateNew Drug Application2022-10-10
etomidateANDA2021-03-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
brain ischemiaHP_0002637D002545I67.82
closed head injuries—D016489—
painEFO_0003843D010146R52
status epilepticusEFO_0008526D013226G41
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01A: Anesthetics, general
— N01AX: Other general anesthetics in atc
— N01AX07: Etomidate
HCPCS
No data
Clinical
Clinical Trials
22 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179—11——2
Postoperative painD010149G89.18——1——1
Acute painD059787R52——1——1
Low back painD017116HP_0003419M54.5——1——1
Ankle injuriesD016512S93.4——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C25—1———1
B-cell chronic lymphocytic leukemiaD015451C91.1—1———1
Multiple myelomaD009101C90.0—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FastingD005215EFO_00027564————4
Healthy volunteers/patients—1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9————11
Ovarian neoplasmsD010051EFO_0003893C56————11
Fallopian tube neoplasmsD005185————11
Ovarian epithelial carcinomaD000077216————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameETOMIDATE
INNetomidate
Description
Etomidate is the ethyl ester of 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid. It is an intravenous general anaesthetic with no analgesic activity. It has a role as an intravenous anaesthetic and a sedative. It is a member of imidazoles and an ethyl ester. It is functionally related to a 1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylic acid.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)c1cncn1[C@H](C)c1ccccc1
Identifiers
PDB—
CAS-ID33125-97-2
RxCUI4177
ChEMBL IDCHEMBL681
ChEBI ID4910
PubChem CID667484
DrugBankDB00292
UNII IDZ22628B598 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,695 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,424 adverse events reported
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