Etonogestrel
Nexplanon, Nuvaring, Veraring (etonogestrel) is a small molecule pharmaceutical. Etonogestrel was first approved as Nuvaring on 2001-10-03.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Nexplanon (discontinued: Implanon)
CombinationsNuvaring, Veraring (generic drugs available since 2019-12-11)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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Clinical
Clinical Trials
65 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | 1 | 5 | — | 6 | ||
| General anesthesia | D000768 | — | — | — | 3 | 1 | 4 | ||
| Hemodynamics | D006439 | — | — | — | 3 | — | 3 | ||
| Hysteroscopy | D015907 | — | — | — | 1 | 1 | 2 | ||
| Coronary artery disease | D003324 | I25.1 | — | — | — | 2 | — | 2 | |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 1 | — | 1 | — | 2 |
| Depression | D003863 | F33.9 | — | — | — | 1 | 1 | 2 | |
| Induced abortion | D000028 | — | — | — | 1 | — | 1 | ||
| Delirium | D003693 | R41.0 | — | — | — | 1 | — | 1 | |
| Confusion | D003221 | F44.89 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | 1 | 2 |
| Critical illness | D016638 | — | 1 | 1 | — | — | 1 | ||
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | T88.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | T14.8 | — | — | — | — | 4 | 4 | |
| Postoperative complications | D011183 | — | — | — | — | 2 | 2 | ||
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 2 | 2 |
| Drug dose-response relationship | D004305 | — | — | — | — | 1 | 1 | ||
| Adrenal insufficiency | D000309 | — | — | — | — | 1 | 1 | ||
| Sepsis | D018805 | A41.9 | — | — | — | — | 1 | 1 | |
| Brain ischemia | D002545 | I67.82 | — | — | — | — | 1 | 1 | |
| Rapid sequence induction and intubation | D000079603 | — | — | — | — | 1 | 1 | ||
| Blood pressure | D001794 | EFO_0004325 | — | — | — | — | 1 | 1 | |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ETONOGESTREL |
| INN | etonogestrel |
| Description | Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug. |
| Classification | Small molecule |
| Drug class | estrogens; progestins |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3C(=C)C[C@@]21CC |
Identifiers
| PDB | — |
| CAS-ID | 54048-10-1 |
| RxCUI | 14584 |
| ChEMBL ID | CHEMBL1531 |
| ChEBI ID | 50777 |
| PubChem CID | 6917715 |
| DrugBank | DB00294 |
| UNII ID | 304GTH6RNH (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
Nexplanon - Organon
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Nexplanon - Merck Sharp & Dohme
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Nuvaring - Organon
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Nuvaring - Merck Sharp & Dohme
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Tabular view
Trends
PubMed Central
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Additional graphs summarizing 2,188 documents
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Safety
Black-box Warning
Black-box warning for: Eluryng, Haloette, Nuvaring
Adverse Events
Top Adverse Reactions
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716 adverse events reported
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